Small Intestinal CD4+ T-Cell Lymphoma Is a Heterogenous Entity With Common Pathology Features Georgia Malamut, Bertrand Meresse, Sophie Kaltenbach, Coralie.

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Small Intestinal CD4+ T-Cell Lymphoma Is a Heterogenous Entity With Common Pathology Features Georgia Malamut, Bertrand Meresse, Sophie Kaltenbach, Coralie Derrieux, Virginie Verkarre, Elizabeth Macintyre, Agnès Ruskone– Fourmestraux, Bettina Fabiani, Isabelle Radford–Weiss, Nicole Brousse, Olivier Hermine, Nadine Cerf–Bensussan, Christophe Cellier Clinical Gastroenterology and Hepatology Volume 12, Issue 4, Pages 599-608.e1 (April 2014) DOI: 10.1016/j.cgh.2013.11.028 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Histologic and immunohistochemical studies. H&E staining of the duodenum of patient 2 showing subtotal villous atrophy, lamina propria, and glandular intraepithelial infiltration by monomorphic small lymphoid cells. (A) H&E, original magnification, ×100; (B and C) H&E, original magnification, ×200; expressing CD3 (D and E), original magnification, ×200. Clinical Gastroenterology and Hepatology 2014 12, 599-608.e1DOI: (10.1016/j.cgh.2013.11.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Histologic and immunohistochemical studies. Duodenum biopsy specimen of patient 2 showing infiltration by monomorphic small-lymphoid cells expressing CD4 (A and B, original magnification, ×200) and Vβ22 (C, original magnification, ×200) but not CD8 (D, original magnification, ×200). Clinical Gastroenterology and Hepatology 2014 12, 599-608.e1DOI: (10.1016/j.cgh.2013.11.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Segments (regions) of tumor-acquired copy number alterations identified by aCGH. Clinical Gastroenterology and Hepatology 2014 12, 599-608.e1DOI: (10.1016/j.cgh.2013.11.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Practical scheme. Diagnosis of intestinal CD4 T-cell lymphoma relies on biopsy analysis including immunohistochemistry and flow cytometry with evidence of infiltration of epithelium and lamina propria by monomorphic small CD4+ T cells expressing a particular Vβ repertoire. For follow-up evaluation, endoscopy and PET scan were repeated at regular intervals. Ab, antibody. Clinical Gastroenterology and Hepatology 2014 12, 599-608.e1DOI: (10.1016/j.cgh.2013.11.028) Copyright © 2014 AGA Institute Terms and Conditions