Stereo-EEG, radiofrequency thermocoagulation and neuropathological correlations in a patient with MRI-negative type IIb focal cortical dysplasia  Rita Garbelli, Roberto Spreafico, Andrea Barbaglia, Laura Rossini, Gloria Milesi, Ileana Zucca, Massimo Cossu, Manuela Bramerio, Laura Tassi  Seizure - European Journal of Epilepsy  Volume 41, Pages 1-3 (October 2016) DOI: 10.1016/j.seizure.2016.06.023 Copyright © 2016 British Epilepsy Association Terms and Conditions

Fig. 1 1.5T and 7T MR images and histopathological correlations in an epileptic patient who underwent resective surgery after RF-THC. (A) Multimodal 3D Slicer illustration of SEEG electrode positioning; (B) presurgical coronal 1.5T T1-weighted image (wi) showing the traces of electrode I (temporal pole) and R (frontal); (C) interictal SEEG recordings from electrode I showing pathognomonic activity in the mesial contacts, characterised by the disruption of the physiological background activity, repetitive “spikes and waves” during wakefulness (top) and pseudoperiodic spiking activity during non-REM sleep (bottom); (D) volume rendering of 7T T2-wi of the temporal specimen showing the reconstructed traces of electrodes A and T, and the volume of the RF-THC lesion (electrode I); (E) the RF-THC lesion can be clearly seen in the 5mm slab and corresponding 7T MRI, a drawing of the length and leads of electrode I is superimposed on the slices; (F) type IIb FCD involving both the grey (green lines) and white matter (red line) adjacent to the RF-THC lesion (blue lines); (G–N) histological details of the FCD showing the presence of dysmorphic neurons (arrows in G and H, and at high magnification in J, K and M), balloon cells (L and N) and normal myelinated fibres (I). Scale bars: 6mm (E); 5.5mm (F); 300μm (G–I); 75μm (J–N). Seizure - European Journal of Epilepsy 2016 41, 1-3DOI: (10.1016/j.seizure.2016.06.023) Copyright © 2016 British Epilepsy Association Terms and Conditions