Volume 4, Issue 1, Pages (January 2018)

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Volume 4, Issue 1, Pages 13-16 (January 2018) Diffuse granulomatous panniculitis associated with anti PD-1 antibody therapy Baijia Jiang, MD, Maria M. Patino, MD, Andrew J. Gross, MD, Stanley P.L. Leong, MD, John C. Moretto, MD, Mohammed Kashani- Sabet, MD, Kevin B. Kim, MD JAAD Case Reports Volume 4, Issue 1, Pages 13-16 (January 2018) DOI: 10.1016/j.jdcr.2017.06.014 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Photograph of granulomatous panniculitis in the patient's right medial leg. B, PET scan image of diffuse granulomatous panniculitis throughout the body, mostly notably in the lower extremities, mimicking widespread subcutaneous metastases. JAAD Case Reports 2018 4, 13-16DOI: (10.1016/j.jdcr.2017.06.014) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Micrographs of granulomatous panniculitis in the patient. A, Subcutaneous tissue. A lobular, septal, and paraseptal lymphohistiocytic infiltrate that is robust and overtly granulomatous in nature in some areas, where multinucleate histiocytes are noted. Some histiocytes and multinucleate histiocytes have a foamy cytoplasm. Asterisk indicates lymphohistiocytic reaction; star indicates residual adipocytes. B, Subcutaneous tissue shows a giant cell reaction (asterisk). C, CD-8 T-cell infiltration in subcutaneous tissue (asterisk). D, PD-L1 in subcutaneous tissue, mostly nonreactive. Asterisk indicates focal reactivity in histiocytes, maybe a few lymphocytes; star indicates mostly nonreactive. (A and B, Hematoxylin-eosin stain; C and D, Immunohistochemical staining; original magnifications: A, ×10; B and C, ×20; D, ×40.) JAAD Case Reports 2018 4, 13-16DOI: (10.1016/j.jdcr.2017.06.014) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions