Volume 52, Issue 1, Pages (July 2007)

Slides:

Advertisements

Similar presentations

Fluorescent In Situ Hybridization (FISH) to Identify Genetic Changes in Fine Needle Biopsy of Lung Lesions Prepared by Jin Jen NCI.

Advertisements

Naomi Fujioka, MD, Christopher A. French, MD, Michael J

Volume 140, Issue 5, Pages (November 2011)

The Origin of the Bone Scan as a Tumour Marker in Prostate Cancer

Standard and variant Philadelphia translocation in a CML patient with different sensitivity to imatinib therapy Stefania Aliano, Gabriella Cirmena, Giuseppina.

Molecular Diagnostics for Head and Neck Pathology

Detection of TMPRSS2-ETS Fusions by a Multiprobe Fluorescence in Situ Hybridization Assay for the Early Diagnosis of Prostate Cancer Qi-Peng Sun, Liao-Yuan.

Volume 67, Issue 4, Pages (April 2015)

Droplet Digital PCR for Absolute Quantification of EML4-ALK Gene Rearrangement in Lung Adenocarcinoma Qiushi Wang, Xin Yang, Yong He, Qiang Ma, Li Lin,

FISH Panel for Leukemic CTCL

Tracy I. George, Joanna E. Wrede, Charles D. Bangs, Athena M

Volume 70, Issue 5, Pages (November 2016)

Control of Prostate Cancer by Transrectal HIFU in 227 Patients

Detection of TMPRSS2-ETS Fusions by a Multiprobe Fluorescence in Situ Hybridization Assay for the Early Diagnosis of Prostate Cancer Qi-Peng Sun, Liao-Yuan.

Volume 52, Issue 3, Pages (September 2007)

Volume 69, Issue 1, Pages (January 2016)

Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe–Based Single-

Volume 61, Issue 4, Pages (April 2012)

Volume 68, Issue 4, Pages (October 2015)

Volume 56, Issue 2, Pages (August 2009)

Tumour Grade, Treatment, and Relative Survival in a Population-based Cohort of Men with Potentially Curable Prostate Cancer Sam Ladjevardi, Gabriel Sandblom,

Nomograms for Bladder Cancer

The Importance of Transurethral Resection in Managing Patients With Urothelial Cancer in the Bladder: Proposal for a Transurethral Resection of Bladder.

Ongoing Gleason Grade Migration in Localized Prostate Cancer and Implications for Use of Active Surveillance Adam B. Weiner, Ruth Etzioni, Scott E. Eggener

Volume 56, Issue 2, Pages (August 2009)

Volume 74, Issue 5, Pages (November 2018)

FISH Analysis for the Detection of Lymphoma-Associated Chromosomal Abnormalities in Routine Paraffin-Embedded Tissue Roland A. Ventura, Jose I. Martin-Subero,

Volume 44, Issue 5, Pages (November 2003)

Luis Martínez-Piñeiro European Urology Supplements

Molecular Tumour Profiling for Detection of Biomarkers in Renal Cell Tumours Kerstin Junker, Jimsgene Sanjmyatav, Joerg Mueller, Thomas Steiner, Heiko.

The Origin of the Bone Scan as a Tumour Marker in Prostate Cancer

Characterization of Fibroblast Growth Factor Receptor 1 in Small-Cell Lung Cancer Anish Thomas, MD, Jih-Hsiang Lee, MD, Zied Abdullaev, PhD, Kang-Seo.

Mark A. Rubin, Gabriele Girelli, Francesca Demichelis European Urology

Volume 66, Issue 2, Pages (August 2014)

FISH Analysis of Crizotinib Target Genes ROS1/ALK/MET in Malignant Mesothelioma Sandra Salvi, PhD, Serena Varesano, PhD, Simona Boccardo, PhD, Jean Louis.

Volume 63, Issue 3, Pages (March 2013)

Tillmann Loch, Pat Fox Fulgham European Urology

Fluorescence in Situ Hybridization Analysis of Immunoglobulin Heavy Chain Translocations in Plasma Cell Myeloma Using Intact Paraffin Sections and Simultaneous.

Volume 61, Issue 6, Pages (June 2012)

Volume 58, Issue 1, Pages (July 2010)

Fluorescence In Situ Hybridization

Clinicopathological and Survival Analysis of Japanese Patients with Resected Non- Small-Cell Lung Cancer Harboring NKX2-1, SETDB1, MET, HER2, SOX2, FGFR1,

Volume 50, Issue 5, Pages (November 2006)

Learning More from Microarrays: Insights from Modules and Networks

CyberKnife in the Treatment of Prostate Cancer: A Revolutionary System

The Development of a Multitarget, Multicolor Fluorescence in Situ Hybridization Assay for the Detection of Urothelial Carcinoma in Urine Irina A. Sokolova,

A Blueprint for Advancing Genetics-Based Cancer Therapy

Increased ALK Gene Copy Number and Amplification are Frequent in Non-small Cell Lung Cancer Marta Salido, MSc, Lara Pijuan, MD, PhD, Luz Martínez-Avilés,

Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma Naoki Yanagawa, MD, PhD, Charles.

Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence Xiaoyu Qu, Claudio Jeldres, Lena Glaskova, Cynthia.

Volume 71, Issue 5, Pages (May 2017)

Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels.

ALK and NRG1 Fusions Coexist in a Patient with Signet Ring Cell Lung Adenocarcinoma Lucia Anna Muscarella, PhD, Domenico Trombetta, PhD, Federico Pio.

Volume 130, Issue 3, Pages (September 2013)

The 20-Yr Outcome in Patients with Well- or Moderately Differentiated Clinically Localized Prostate Cancer Diagnosed in the Pre-PSA Era: The Prognostic.

Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients Leila Aghili, Jasmine Foo, James.

Amplification Patterns of Three Genomic Regions Predict Distant Recurrence in Breast Carcinoma Lisa M. Davis, Cole Harris, Lei Tang, Patti Doherty, Peter.

Chromosomal Abnormalities in Non-Small Cell Lung Carcinomas and in Bronchial Epithelia of High-Risk Smokers Detected by Multi-Target Interphase Fluorescence.

Daynna J. Wolff, Adam Bagg, Linda D. Cooley, Gordon W. Dewald, Betsy A

Role of Chromosome 3q Amplification in Lung Cancer

The Detection of t(14;18) in Archival Lymph Nodes

Long Polymerase Chain Reaction-Based Fluorescence in Situ Hybridization Analysis of Female Carriers of X-Linked Chronic Granulomatous Disease Deletions

High MET Gene Copy Number Leads to Shorter Survival in Patients with Non-small Cell Lung Cancer Heounjeong Go, MD, Yoon Kyung Jeon, MD, PhD, Hyo Jin.

Erratum Journal of Thoracic Oncology

NUT Rearrangement is Uncommon in Human Thymic Epithelial Tumors

Arnaud Uguen, MD, PhD Journal of Thoracic Oncology

Immunohistochemistry is a Reliable Screening Tool for Identification of ALK Rearrangement in Non–Small-Cell Lung Carcinoma and is Antibody Dependent

Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients Leila Aghili, Jasmine Foo, James.

Volume 54, Issue 1, Pages (July 2008)

ALK Gene Rearrangements: A New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer Benjamin Solomon, MBBS, PhD, Marileila.

Presentation transcript:

Volume 52, Issue 1, Pages 116-125 (July 2007) Relative Copy Number Gain of MYC in Diagnostic Needle Biopsies is an Independent Prognostic Factor for Prostate Cancer Patients Franclim R. Ribeiro, Rui Henrique, Ana T. Martins, Carmen Jerónimo, Manuel R. Teixeira European Urology Volume 52, Issue 1, Pages 116-125 (July 2007) DOI: 10.1016/j.eururo.2006.09.018 Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 1 Disease-specific survival curves using established clinical variables. (A) Cases grouped according to clinical stage at diagnosis. (B) Cases grouped by Gleason score categories. European Urology 2007 52, 116-125DOI: (10.1016/j.eururo.2006.09.018) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 2 Representative fluorescent in situ hybridization images from selected prostate biopsies analyzed with a dual-color (green and red) MYC probe and a chromosome 18 centromeric probe (blue). Cells presenting MYC/CEP18 ratios of 1.0 (A and B), 1.5 (C), 3.0 (D), 2.0 (E), 2.5 (F), and 2.3 (G) are presented (sample identifications (IDs): B13, B12, B27, B22, B26, B23, and B28, respectively; see Table 2). European Urology 2007 52, 116-125DOI: (10.1016/j.eururo.2006.09.018) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 3 Fluorescent in situ hybridization (FISH) patterns indicative of MYC rearrangements in prostate carcinoma biopsies. (A) Nuclei with three centromeric signals for chromosome 18 (blue), two dual-color (green and red) signals representing normal copies of MYC, and one additional MYC3′ signal (sample identification [ID]: B08). (B) Nuclei showing amplifications of MYC5′, in addition to the two normal copies of MYC (sample ID: B16). (C) Nuclei presenting a slight separation of MYC3′ and MYC5′ probes suggesting an intrachromosomal rearrangement affecting this gene (sample ID: B31). (D) Nuclei with a FISH pattern suggesting an internal duplication within one of the MYC genes (sample ID: A07). (E) Nuclei with a break-apart pattern suggesting a translocation affecting the MYC gene (sample ID: A04). European Urology 2007 52, 116-125DOI: (10.1016/j.eururo.2006.09.018) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 4 Disease-specific survival curves based on 8q status assessed by three-color fluorescent in situ hybridization. (A) All cases, grouped according to the respective MYC/CEP18 ratio. (B) Samples with Gleason score=7. (C) Samples from patients with clinical stage II or III disease at diagnosis. European Urology 2007 52, 116-125DOI: (10.1016/j.eururo.2006.09.018) Copyright © 2006 European Association of Urology Terms and Conditions