Chromosomal complement and clinical relevance of multinucleated embryos in PGD and PGS cycles Ahmet Yilmaz, Li Zhang, Xiao Yun Zhang, Weon-Young Son,

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Chromosomal complement and clinical relevance of multinucleated embryos in PGD and PGS cycles Ahmet Yilmaz, Li Zhang, Xiao Yun Zhang, Weon-Young Son, Hananel Holzer, Asangla Ao Reproductive BioMedicine Online Volume 28, Issue 3, Pages 380-387 (March 2014) DOI: 10.1016/j.rbmo.2013.11.003 Copyright © 2013 Terms and Conditions

Figure 1 Representative micrographs of multinucleated blastomeres subjected to fluorescent in situ hybridization (FISH) analysis. Multiple nuclei in the same blastomere seen under the light (A) and inverted (B) microscope before FISH analysis. (C) FISH using probes for chromosomes 13 (red), 16 (aqua), 18 (blue), 21 (green) and 22 (gold) in a multinucleated blastomere showed trisomy 21 and monosomy 22 in both nuclei (NB: the gold signal for chromosome 22 in the left nucleus appears light yellow). (D) Two nuclei with identical chromosomal complement obtained from a multinucleated blastomere with nullisomy for chromosome 13 and monosomy for chromosomes 16, 18, 21 and 22 in each nucleus. Magnification=×400 (A), ×200 (B) and ×1000 (C and D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Reproductive BioMedicine Online 2014 28, 380-387DOI: (10.1016/j.rbmo.2013.11.003) Copyright © 2013 Terms and Conditions