Rejuvenation by Therapeutic Elimination of Senescent Cells

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Rejuvenation by Therapeutic Elimination of Senescent Cells Paul Krimpenfort, Anton Berns Cell Volume 169, Issue 1, Pages 3-5 (March 2017) DOI: 10.1016/j.cell.2017.03.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Tissue Rejuvenation by FOXO-DRI Treatment (A) Environmental stress (yellow lightning bolt) causes damage to individual cells within healthy tissue. (B) Nuclear sequestration of p53 (red) by FOXO4 (yellow) leads to senescence of damaged cells, which secrete SASP factors (orange speckles) that damage healthy surrounding cells. (C) FOXO4-DRI (teal) treatment releases p53 from FOXO4, enabling its translocation to mitochondria and activation of cytochrome-c-mediated apoptosis in the damaged cell. (D) Apoptotic cells are removed from the system and the affected tissue can rejuvenate. Cell 2017 169, 3-5DOI: (10.1016/j.cell.2017.03.014) Copyright © 2017 Elsevier Inc. Terms and Conditions