Statin Selection Aimed to Reduce New-Onset DM Risk:

Our Goals Are to Improve Our Knowledge of:

Statins and New-Onset T2D: RCT Publication Timeline

JUPITER: Rosuvastatin Therapy and Diabetes Risk

Statin Diabetogenicity

Statin Diabetogenicity (cont)

How Statins Lower Cholesterol: The Mechanism

Apoptosis of Beta Cells

Clinical Risk Factors

Hypothesis History Reversed

Certain Statins Increase the Risk of New-Onset T2D

Risk of New-Onset T2D With Statin by Age

HMG-CoA Reductace

J-PREDICT Study Design

Primary Outcome: Cumulative Incidence of Diabetes

Pitavastatin and Glucose Endpoint

Lifestyle

Patient Education -- Team Approach

Thoughtful Statin Consideration

Summary

Summary (cont)

Abbreviations