A new cause of Zollinger–Ellison syndrome: Non–Small cell lung cancer

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Presentation transcript:

A new cause of Zollinger–Ellison syndrome: Non–Small cell lung cancer Alaa Abou–Saif, Junyi Lei, Thomas J. McDonald, Subrata Chakrabarti, Irving F. Waxman, Homayoun Shojamanesh, David S. Schrump, David E. Kleiner, Fathia Gibril, Robert T. Jensen Gastroenterology Volume 120, Issue 5, Pages 1271-1278 (April 2001) DOI: 10.1053/gast.2001.23242 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Results of tumor localization studies. (A) The admission chest radiograph showed a left lower lung mass indicated by the designation “tumor.” (B) The result of the somatostatin receptor scintigraphy scan with physiologic distribution of the tracer without evidence of abnormal uptake is shown. (C and D) The results of a chest CT scan at 2 different levels on 2 different dates. Gastroenterology 2001 120, 1271-1278DOI: (10.1053/gast.2001.23242) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Gross and histologic features of the lung tumor. (A) A histologic section of the tumor is shown in which the tumor cells show lymphatic invasion. (B) A cross section of the surgical section shows the relationship between the tumor and adjacent tissues like the lung and bronchus. Gastroenterology 2001 120, 1271-1278DOI: (10.1053/gast.2001.23242) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Results of immunohistochemical staining of the tumor. (A) An H&E stain is shown (original magnification 40×). (B) The positive staining for gastrin and synaptophysin (a general neuroendocrine tumor marker) and (C) the positive staining for chromogranin A (another neuroendocrine tumor marker) and for cytokeratin Mak-6 (original magnification 20×). Gastroenterology 2001 120, 1271-1278DOI: (10.1053/gast.2001.23242) Copyright © 2001 American Gastroenterological Association Terms and Conditions