Lymphovascular Invasion as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Nathan M. Mollberg, DO,

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Lymphovascular Invasion as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Nathan M. Mollberg, DO, Carrie Bennette, MPH, Eric Howell, MD, Leah Backhus, MD, Beth Devine, PhD, PharmD, Mark K. Ferguson, MD The Annals of Thoracic Surgery Volume 97, Issue 3, Pages 965-971 (March 2014) DOI: 10.1016/j.athoracsur.2013.11.002 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow diagram shows literature search for eligible studies. (LVI = lymphovascular invasion; NSCLC = non-small cell lung carcinoma.) The Annals of Thoracic Surgery 2014 97, 965-971DOI: (10.1016/j.athoracsur.2013.11.002) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plot shows the unadjusted association between lymphovascular invasion and recurrence-free survival in stage I non-small cell lung cancer patients. The solid squares denote mean difference, the horizontal lines represent the 95% confidence intervals (CI), and the diamond denotes the weighted mean differences. (HR = hazard ratio.) The Annals of Thoracic Surgery 2014 97, 965-971DOI: (10.1016/j.athoracsur.2013.11.002) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Forest plot shows the association between lymphovascular invasion and recurrence-free survival in stage I non-small cell lung cancer patients, adjusted for confounders. The solid squares denote mean difference, the horizontal lines represent the 95% confidence intervals (CI), and the diamond denotes the weighted mean differences. (HR = hazard ratio.) The Annals of Thoracic Surgery 2014 97, 965-971DOI: (10.1016/j.athoracsur.2013.11.002) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Forest plot shows the unadjusted association between lymphovascular invasion and overall survival in stage I non-small cell lung cancer patients. *Study by Kato and colleagues [6] used disease-specific survival. The solid squares denote mean difference, the horizontal lines represent the 95% confidence intervals (CI), and the diamond denotes the weighted mean differences. (HR = hazard ratio.) The Annals of Thoracic Surgery 2014 97, 965-971DOI: (10.1016/j.athoracsur.2013.11.002) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Forest plot shows the association between lymphovascular invasion and overall survival in stage I non-small cell lung cancer patients, adjusted for confounders. The solid squares denote mean difference, the horizontal lines represent the 95% confidence intervals (CI), and the diamond denotes the weighted mean differences. (HR = hazard ratio.) The Annals of Thoracic Surgery 2014 97, 965-971DOI: (10.1016/j.athoracsur.2013.11.002) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions