Dedicated mTEC Progenitors Stay True, Even into Adulthood

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Dedicated mTEC Progenitors Stay True, Even into Adulthood Korosh Kianizad, Juan Carlos Zúñiga-Pflücker Immunity Volume 41, Issue 5, Pages 675-676 (November 2014) DOI: 10.1016/j.immuni.2014.11.008 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Schematic View of Progenitor-Progeny Relationships of Different TEC Subtypes The adult thymus contains a self-renewing pool of stem cells, which can give rise to both cTECs and mTECs. Additionally, a pool of self-renewing Cld3,4hiSSEA-1+ mTECSCs can give rise exclusively to mTECs. However, it is unknown whether these mTECSCs arise from the common adult TEC stem cell or whether they are embryonically derived. Additionally, the immediate progeny of the common TEC stem cell remains to be definitely identified. Immunity 2014 41, 675-676DOI: (10.1016/j.immuni.2014.11.008) Copyright © 2014 Elsevier Inc. Terms and Conditions