by Masako Moriuchi, Hiroyuki Moriuchi, and Anthony S. Fauci

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by Masako Moriuchi, Hiroyuki Moriuchi, and Anthony S. Fauci GATA-1 Transcription Factor Transactivates the Promoter for CCR5, a Coreceptor for Human Immunodeficiency Virus Type 1 Entry by Masako Moriuchi, Hiroyuki Moriuchi, and Anthony S. Fauci Blood Volume 93(4):1433-1435 February 15, 1999 ©1999 by American Society of Hematology

Masako Moriuchi et al. Blood 1999;93:1433-1435 ©1999 by American Society of Hematology

Masako Moriuchi et al. Blood 1999;93:1433-1435 ©1999 by American Society of Hematology

GATA-1 upregulates CCR5 promoter activity through interaction with GATA elements on the promoter. GATA-1 upregulates CCR5 promoter activity through interaction with GATA elements on the promoter. Twenty million PM1 cells were transfected with 10 μg of the indicated CCR5 promoter-luciferase construct along with 10 μg of either pMT2T or pMT-GATA-1, and luciferase assays were performed 40 hours after transfection, as described previously.4 Results are reported as means ± SD from four independent experiments. Similar results were obtained for THP-1 cells (data not shown). Masako Moriuchi et al. Blood 1999;93:1433-1435 ©1999 by American Society of Hematology