Cardioprotective SUR2A promotes stem cell properties of cardiomyocytes

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Cardioprotective SUR2A promotes stem cell properties of cardiomyocytes Stephen C. Land, David J. Walker, Qingyou Du, Aleksandar Jovanović International Journal of Cardiology Volume 168, Issue 5, Pages 5090-5092 (October 2013) DOI: 10.1016/j.ijcard.2013.07.182 Copyright © 2013 The Authors Terms and Conditions

Fig. 1 Infection of fetal heart by SUR2A results in decreased expression of cardiomyocyte expression markers. Fetal hearts were collected at E12.5 stage. Original real time RT-PCR progress curves for SUR2A, troponin C, GATA 4 and housekeeping gene BMZ and corresponding graphs depicting cycling threshold. Each bar represents mean±S.E.M. (n=3). *P<0.05. Infection of heart with SUR2A increased SUR2A mRNA levels for ~10 times and decreased troponin C and GATA 4 mRNA for ~30 and ~4 times. Infection with SUR2A did not affect BMZ at all. International Journal of Cardiology 2013 168, 5090-5092DOI: (10.1016/j.ijcard.2013.07.182) Copyright © 2013 The Authors Terms and Conditions

Fig. 2 Infection of fetal heart by SUR2A results in suppressed ERK activity and heart shifted towards less differentiated state. Fetal hearts were collected at E12.5 stage. A. Original Western blotting and corresponding graphs of fetal hearts infected with luciferase (control; luciferase was used as a control as we have determined that infection with luciferase does not affect phospho- or total ERK1/2) and SUR2A. While total ERK1/2 was not affected by SUR2A, phosphorylation of ERK1/2 was. Each bar represents mean±S.E.M. (n=3; n is defined as the number of infected fetal hearts). *P<0.05. B. Original real time RT-PCR progress curves for Oct4, Sox 2 and nanog and corresponding graphs depicting cycling threshold. Each bar represents mean±S.E.M. (n=3). *P<0.05. International Journal of Cardiology 2013 168, 5090-5092DOI: (10.1016/j.ijcard.2013.07.182) Copyright © 2013 The Authors Terms and Conditions