Reversing Neurodegeneration:A Promise Unfolds

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

Irreplaceability of Neuronal Ensembles after Memory Allocation Naoki Matsuo Cell Reports Volume 11, Issue 3, Pages (April 2015) DOI: /j.celrep

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

PARTIAL LOSS OF TIP60 SLOWS MID-STAGE NEURODEGENERATION IN A SPINOCEREBELLAR ATAXIA TYPE 1 (SCA1) MOUSE MODEL -KRISTEN M. GEHRKING, J. MICHAEL ANDRESEN,

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression Charikleia Papadopoulou, Guillaume Guilbaud, Davide Schiavone,

Binding of Secretory Precursor Polypeptides to a Translocon Subcomplex Is Regulated by BiP Susan K Lyman, Randy Schekman Cell Volume 88, Issue 1, Pages.

Cultured Schwann Cells Constitutively Express the Myelin Protein P0 Lili Cheng, Anne W Mudge Neuron Volume 16, Issue 2, Pages (February 1996) DOI:

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis Tzumin Lee, Liqun Luo Neuron Volume 22, Issue 3,

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Chi-Bin Chien: A Tribute

Chapter 08 The T Cell Receptor: Proteins and Genes

A Circuit Mechanism for Neurodegeneration

A Constraint on cAMP Signaling

Neuronal Differentiation

IRS-1: Auditing the effectiveness of mTOR inhibitors

Ricky L. Langley Wilderness & Environmental Medicine

Peptides Signal Mitochondrial Stress

Bettina Schreiner, Melanie Greter Cell Stem Cell

p53 and Apoptosis: It's Not Just in the Nucleus Anymore

Annapoorni Rangarajan, Sue J. Hong, Annie Gifford, Robert A. Weinberg

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Type 3 Deiodinase in Hypoxia: To Cool or to Kill?

Volume 134, Issue 5, Pages (May 2008)

The Immunoproteasome Cleans up after Inflammation

In This Issue Cell Volume 158, Issue 5, (August 2014)

Structural Surprises from the Flaviviruses and Alphaviruses

Michael L. Frisoli, John E. Harris

Can U Turn ILC2s Up? Paul A. Muller, Daniel Mucida Cell

Volume 3, Issue 4, Pages (April 2003)

PAR-1 for the Course of Neurodegeneration

IRS-1: Auditing the effectiveness of mTOR inhibitors

Volume 152, Issue 1, (January 2013)

Volume 127, Issue 1, (October 2006)

Volume 130, Issue 6, (September 2007)

Current Compensation in Neuronal Homeostasis

Glucose Metabolism: A Sweet Relief of Alzheimer’s Disease

Type 3 Deiodinase in Hypoxia: To Cool or to Kill?

Volume 148, Issue 3, Pages (March 2015)

Volume 143, Issue 6, (December 2010)

Proteins in Plant Brassinosteroid Signaling

Brain Canada: One Brain One Community

Polycomb Repression under the Skin

Bettina Schreiner, Melanie Greter Cell Stem Cell

Volume 38, Issue 3, Pages (May 2003)

The Plasticity of Aging: Insights from Long-Lived Mutants

The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer: Still Following the Right TRAIL? Emmet E. McGrath, MB, PhD Journal of Thoracic.

SCOPing out Proteases in Long-Term Memory

Volume 163, Issue 4, (November 2015)

Volume 4, Issue 3, Pages (March 2018)

All Roads Lead to the Ribosome

Volume 163, Issue 2, (October 2015)

SCOPing out Proteases in Long-Term Memory

Neurodegeneration: Paying It Off with Sleep

Brain Canada: One Brain One Community

Volume 134, Issue 6, (September 2008)

David Hubel and Torsten Wiesel

Volume 18, Issue 5, Pages R198-R202 (March 2008)

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Volume 3, Issue 4, Pages (April 2003)

Presentation transcript:

Reversing Neurodegeneration:A Promise Unfolds Harry T Orr, Huda Y Zoghbi Cell Volume 101, Issue 1, Pages 1-4 (March 2000) DOI: 10.1016/S0092-8674(00)80617-0 Copyright © 2000 Cell Press Terms and Conditions

Figure 1 A Model of Polyglutamine-Induced Neurodegeneration and Its Reversal (A) Expression of a mutant peptide with expanded polyglutamine (Q) tract leads to neuronal degeneration and eventual death. Note that both aggregated and solitary protein induce neuronal dysfunction that precedes death. (B) Turning off mutant protein expression gives the neuron enough of a reprieve to clear the mutant protein by the chaperone/ubiquitin-proteasome pathway (UPP) and subsequently recover at least some function. Cell 2000 101, 1-4DOI: (10.1016/S0092-8674(00)80617-0) Copyright © 2000 Cell Press Terms and Conditions