What does this protein make up or do? Chapter 5: Chromosome 5 Name of Protein DNA Sequence Solute Carrier Family Chromosome 5 49755 Name of Gene SLC22A4 transcription Amino acid sequence mRNA 551 aa translation Cytoplasm A Cell Nucleus What does this protein make up or do? Makes up Chromosome 5 Condition/Disease Crohn’s Disease

Description of Glaucoma Symptoms and characteristics Abdominal pain. Often cramping and intermittent. The abdomen may be sore when touched. Abdominal pain may feel like a dull, constant ache depending on the location of inflammation Diarrhea. Some people have diarrhea many times a day and need to wake up at night to go to the bathroom Unintended weight loss. Ongoing symptoms, such as vomiting or diarrhea, can lead to substantial weight loss Normal Vision As viewed by a person with glaucoma Pictures used with permission from URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp

Description of Crohn’s Disease(cont.) Who is affected? Age. Crohn's disease can occur at any age, but you're likely to develop the condition when you're young. Most people who develop Crohn's disease are diagnosed before they're 30 years old Ethnicity. Although Crohn's disease can affect any ethnic group, whites and people of Eastern European (Ashkenazi) Jewish descent have the highest risk. Cigarette smoking. Cigarette smoking is the most important controllable risk factor for developing Crohn's disease. Smoking also leads to more severe disease and a greater risk of having surgery. If you smoke, it's important to stop. Family history. You're at higher risk if you have a close relative, such as a parent, sibling or child, with the disease. As many as 1 in 5 people with Crohn's disease has a family member with the disease. Outlook or quality of life: To compare health-related quality of life in Crohn's disease patients with that in other patients and healthy controls, and between medically and surgically treated Crohn's disease patients, and to correlate health-related quality of life with Crohn's disease activity.

References NCBI. Genes and Disease: Crohn’s Disease[online]. 2002. [cited 2015 March 3]. Available at URL: http://www.ncbi.nlm.nih.gov/pubmed/12197839 NCBI. Entrez [online]. 2003. [cited 2004 July 14]. Available at URL:http://www.mayoclinic.org/diseases-conditions/crohns-disease/basics/risk-factors/con-20032061 http://ghr.nlm.nih.gov/chromosome/5 Researched By: KS