Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia Hiroyuki Hayashi,

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Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia Hiroyuki Hayashi, Yohei Miyagi, Akiko Sekiyama, Sachiko Yoshida, Sayumi Nakao, Noriko Okamoto, Kazutaka Koganei, Akira Sugita Journal of Crohn's and Colitis Volume 6, Issue 1, Pages 112-115 (February 2012) DOI: 10.1016/j.crohns.2011.08.009 Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 1 Rectosigmoidal area of the resected specimen. Ulcerative main tumor (x) and satellite adenocarcinomas (arrows). Journal of Crohn's and Colitis 2012 6, 112-115DOI: (10.1016/j.crohns.2011.08.009) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 2 Main tumor consists of small cell carcinoma (left) and adenocarcinoma (right) (HE stain). Journal of Crohn's and Colitis 2012 6, 112-115DOI: (10.1016/j.crohns.2011.08.009) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 3 Small cell carcinoma: solid sheet of small cells with hyperchromatic nuclei, finely granular chromatin and scant cytoplasm (HE stain). Journal of Crohn's and Colitis 2012 6, 112-115DOI: (10.1016/j.crohns.2011.08.009) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 4 Small cell carcinoma: tumor cells are positive for synaptophysin immunostain. Journal of Crohn's and Colitis 2012 6, 112-115DOI: (10.1016/j.crohns.2011.08.009) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 5 Electropherograms of TP53 mutation analysis: All lesions showed an identical somatic single nucleotide alteration of C to T transition at the codon 331. Arrows indicate mutated nucleotide in each panel. AC, adenocarcinoma; SCC, small cell carcinoma. Journal of Crohn's and Colitis 2012 6, 112-115DOI: (10.1016/j.crohns.2011.08.009) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Supplementary Figure S1 Microscopic view of the lesions before (left) and after (center) microdissection and the dissected cells (right): a. dysplasia, b. satellite adenocarcinoma, c. adenocarcinoma associated with small cell carcinoma, d. small cell carcinoma. Journal of Crohn's and Colitis 2012 6, 112-115DOI: (10.1016/j.crohns.2011.08.009) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions