Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose Scott.

Slides:

Advertisements

Similar presentations

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.) Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Advertisements

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Marija Geroldinger-Simic, MD, Thomas Zelniker,

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden Matthew S. Perzanowski,

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy Satya D. Narisety,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose Scott P. Commins, MD, PhD, Hayley R. James,

Role of the basophil activation test in the diagnosis of local allergic rhinitis Enrique Gómez, PhD, Paloma Campo, MD, PhD, Carmen Rondón, MD, PhD, Esther.

Asian ladybugs (Harmonia axyridis): A new seasonal indoor allergen

Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden Matthew S. Perzanowski,

Atopic dermatitis: Age and race do matter!

Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,

Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds Sofía Sirvent, PhD, Belén Cantó, BSc, Javier Cuesta-Herranz, MD, PhD,

Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy Julie Wang, MD,

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Diagnosis of red meat allergy with antigen-specific IgE tests in serum

Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies

Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy Eva Untersmayr, MD, Helle Vestergaard, Hans-Jørgen.

No evidence of intrauterine sensitization against inhalant allergens

Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,

Correction Journal of Allergy and Clinical Immunology

Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease Monica G. Lawrence, MD, Judith A. Woodfolk, MBChB,

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults Christian Lupinek, MD,

IgE in the diagnosis and treatment of allergic disease

Simultaneous detection of total and allergen-specific IgE by using purified allergens in a fluorescent multiplex array Eva-Maria King, PhD, Lisa D. Vailes,

Targeting Fel d 1 to FcγRI induces a novel variation of the TH2 response in subjects with cat allergy Kathryn E. Hulse, BS, Amanda J. Reefer, MS, Victor.

Targeting allergen to FcγRI reveals a novel TH2 regulatory pathway linked to thymic stromal lymphopoietin receptor Kathryn E. Hulse, PhD, Amanda J. Reefer,

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy Satya D. Narisety,

Comparison of a new Skin Prick Test Tape with the conventional skin prick test Zhengpeng Gong, MD, Zhijie Yang, PhD, Ran Wu, MD, Huiping Ye, MD, PhD,

Reply Journal of Allergy and Clinical Immunology

Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine in vitro extract potency.

Kerstin Bauermeister, MSc, Barbara K

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge John W. Steinke, PhD, Shawna L. Pochan,

John A. Eckman, MD, Patricia M

Casein-related anaphylaxis after use of an Everlast kickboxing glove

Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children Yvonne Resch, MSc, Sven Michel, MSc, Michael Kabesch, MD,

Jason B. Price, MD, Adnan Divjan, William R. Montfort, PhD, Kirstie H

Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen– allergic patients Verena Niederberger, MD, Katharina Marth, MD,

Skin prick test to egg white provides additional diagnostic utility to serum egg white– specific IgE antibody concentration in children Adina Kay Knight,

Cockroach allergens: Coping with challenging complexity

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Dawn Cooper, Jonathan Hales, Richard Camp

Accuracy of US Food and Drug Administration–cleared IgE antibody assays in the presence of anti-IgE (omalizumab) Robert G. Hamilton, PhD, DABMLI Journal.

New pathways for itching in patients with atopic dermatitis?

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Marija Geroldinger-Simic, MD, Thomas Zelniker,

Cat IgA, representative of new carbohydrate cross-reactive allergens

Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3- galactose Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Hayley.

Evaluation of different techniques for washing cats: Quantitation of allergen removed from the cat and the effect on airborne Fel d 1 David B. Avner,

Identification of crab proteins that elicit IgE reactivity in snow crab–processing workers Beth V. Gill, MD, Timothy R. Rice, André Cartier, MD, Denise.

The effectiveness of Allerpet/c in reducing the cat allergen Fel d 1

The role of indoor allergens in chronic allergic disease

Allergy to human seminal fluid: Cross-reactivity with dog dander

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis Eva Gros, MSc, Caroline Bussmann,

Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence Elizabeth A. Erwin, MD, Eva Rönmark, PhD, Kristin Wickens,

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Mediator release assay for assessment of biological potency of German cockroach allergen extracts Anna H. Nowak-Wegrzyn, MD, Ramon Bencharitiwong, BS,

The natural history of milk allergy in an observational cohort

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis Jörg Fischer, MD,

IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries Merima Bublin, MSc,

Role of Art v 3 in pollinosis of patients allergic to Pru p 3

The effects of gastric digestion on codfish allergenicity

Natural history of cow’s milk allergy

Carl Hamsten, MSc, PhD, Thi Anh T

Presentation transcript:

Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose Scott P. Commins, MD, PhD, Shama M. Satinover, MS, Jacob Hosen, BS, Jonathan Mozena, MD, Larry Borish, MD, Barrett D. Lewis, MD, Judith A. Woodfolk, MBChB, PhD, Thomas A.E. Platts-Mills, MD, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 2, Pages 426-433.e2 (February 2009) DOI: 10.1016/j.jaci.2008.10.052 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Representative SPT and intradermal test results in patients with IgE antibodies to α-gal. A, SPTs were performed on the volar surface of the arm with commercially available skin testing reagents at 1:20 wt/vol after histamine reactivity (denoted by +) was verified. Right column of SPTs: B, beef; C, chicken; L, lamb; P, pork; T, turkey, Co, codfish. Left column of SPTs: DP, Dermatophagoides pteronyssinus; DF, Dermatophagoides farinae; CR, cockroach; C, cat; D, dog; G, grass. B, Intradermal testing was performed with 0.03 mL of a 1:100 dilution of commercially available reagents (ie, 1:2000 wt/vol) with a 25-gauge needle. C, SPTs with commercially available reagents (left) and fresh meat extract (right) in which values in millimeters represent the greatest diameter of wheal response. NR, Nonreactive. The experiments in Fig 1, A and B, were performed on the same patient during a single clinic visit and were measured 15 minutes after placement. Negative controls were 50% glycerin/saline for SPTs and buffered saline for intradermal tests. Journal of Allergy and Clinical Immunology 2009 123, 426-433.e2DOI: (10.1016/j.jaci.2008.10.052) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, IgE antibody binding to allergens in serum samples from 24 patients with IgE antibodies to α-gal. The horizontal lines indicate geometric mean values. Numbers below the limit of detection indicate the number of negative values for each allergen. Four results for α-gal were greater than 100 IU/mL and are listed in Table II. One result each for beef, cat, and dog were greater than 100 IU/mL. ‡Chicken, turkey, and fish have a significantly lower prevalence of positive results (P < .01) compared with α-gal, beef, pork, and lamb by means of χ2 analysis. Abs, Antibodies. B, Correlation of IgE antibodies to α-gal and IgE antibodies to beef in patients with IgE antibodies to α-gal. C, Correlation of IgE antibodies to cat and IgE antibodies to dog in patients with IgE antibodies to α-gal. D, Correlation of IgE antibodies to cat and IgE to Fel d 1 in patients with IgE antibodies to α-gal. Journal of Allergy and Clinical Immunology 2009 123, 426-433.e2DOI: (10.1016/j.jaci.2008.10.052) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Absorption of sera with sepharose-bound α-gal or sepharose-bound bovine thyroglobulin (BT). A, Sera from patients (n = 8) with IgE antibodies to α-gal were incubated overnight with α-gal bound to sepharose beads (gray bars), bovine thyroglobulin bound to sepharose beads (red bars), or mock-coupled sepharose beads (blue bars) expressed as specific IgE antibodies and adjusted for transferrin concentration. Error bars indicate 95% CIs. B, Sera from patients (n = 4) with atopic dermatitis (AD) treated as described for Fig 3, A. C, Sera from 2 individual patients with IgE antibodies to α-gal (subjects 18 and 115) and 2 patients with atopic dermatitis (AD1 and AD2) treated as described for Fig 3, A. Journal of Allergy and Clinical Immunology 2009 123, 426-433.e2DOI: (10.1016/j.jaci.2008.10.052) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions