HUMAN PHYSIOLOGY Instructor : Dr. Norm Garrison Office: HHS 3152 Phone: (540)568-3047 Office Hours: 1-3:30 W; 9-11:30 Th E-mail: garrisne@jmu.edu URL: http://csm.jmu.edu/biology/garrisne/ Physiology Web Page username: physiology password : bio270jm

Prerequisites CHEM 120 or 131 (Grade of C- or higher) MATH 220 If you do not meet these prerequisites and wish to remain in the course, please e-mail me to schedule an appointment. No mad rush to the front of the room to see me after class, please! BIO majors: This course will count toward graduation, but not your major.

Grades Max Expected Actual Difference 75 56.25 40.39 15.86 75 56.25 40.39 15.86 100 75 56.3 18.7 100 75 49.93 25.07 125 93.75 71 22.75 Total deficit of points 82.38 Points available from assignments 100

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Lab Instructors

INTRODUCTION A. Definitions B. History C. Levels of Organization D. Homeostasis

A. Definitions

pneumonoultramicroscopicsilicovolcanoconiosis

B. History 1. William Harvey (1628) - Continuous circulation of blood. However, note the following quotation from the early Chinese literature. "All the blood in the body is under control of the heart.... The blood current flows continuously in a circle and never stops."

B. History (Cont’d) 2. Wöhler, Conrad (1828) - Vitalism vs Mechanism NH4CNO ----------> H2N -CO-NH2 ammonium cyanate urea (inorganic) (Organic)

B. History (Cont’d) 3. Claude Bernard (1850) - "Father" of modern physiology. Noted for use of experimental approach. Studied the Following: a. Pancreatic digestion b. Glycogenic function of liver c. The vasomotor nerves d. Action of drugs on the body (e.g. curare blocks neuromyal junction)

B. History (Cont’d) His commitment to the scientific method is seen in the following quote: “I believe, in a word, that the true scientific method confines the mind without suffocating it, leaves it as far as possible face to face with itself, and guides it, while respecting the creative originality and spontaneity which are its most precious qualities.”.

C. Levels of Organization 1. Atoms 6. Organs 2. Molecules 7. Organ Systems 3. Organelles 8. Organisms 4. Cells 9. Populations 5. Tissues 10. Societies

D. Homeostasis Term coined by Walter Cannon. Refers to "maintenance of constant internal conditions", both internal and external.

Negative Feedback Control

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