Representation of Adhesion GPCR interactions within the NTFs

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Presentation transcript:

Representation of Adhesion GPCR interactions within the NTFs Representation of Adhesion GPCR interactions within the NTFs. As examples, interactions of the Adhesion GPCRs (A) ADGR5 (CD97), (B) ADGRG1 (GPR56), (C) ADGRG6 (GPR126), (D and E) ADGRL1 (latrophilin-1), and (F) ADGRB3 (BAI3) are depicted. Representation of Adhesion GPCR interactions within the NTFs. As examples, interactions of the Adhesion GPCRs (A) ADGR5 (CD97), (B) ADGRG1 (GPR56), (C) ADGRG6 (GPR126), (D and E) ADGRL1 (latrophilin-1), and (F) ADGRB3 (BAI3) are depicted. The interactions of the binding partners with the receptors are shown in cis and trans configurations. Arrows indicate the protein domains—as far as these are known—that facilitate the interactions. The figure also shows some of the solved three-dimensional structures of protein domains, including RBL domain (PDB ID 2JX9) and tissue transglutaminase 2 (PDB ID 1KV3) obtained from the PDB database. The three-dimensional structure of chondroitin sulfate B (a glycosaminoglycan) has been obtained from the PubChem Compound Database (compound ID: 32756). CUB, Cs1 and Csr/Uegf/BMP1; EGF_CA, calcium-binding EGF; FG–GAP, phenylalanine-glycine–glycine-alanine-proline; GPI, glycosylphosphatidylinositol; HRM, hormone receptor motif; LRR, leucine-rich repeat; LRRCT, leucine-rich repeat C-terminal; LRRNT, leucine-rich repeat N-terminal; NHL, NCL-1, HT2A, and Lin-41; PH, Pleckstrin homology; RBL, rhamnose-binding lectin; RGD, arginine-glycine-aspartate; START, StAR-related lipid-transfer; YD, tyrosine-aspartate. Jörg Hamann et al. Pharmacol Rev 2015;67:338-367 Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics