Cardiac disease and pregnancy

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Presentation transcript:

Cardiac disease and pregnancy Dr. Minoo Movahedi

انواع دریچه‌های مصنوعی قلب کدامند؟

Prosthetic heart valves: Mechanical Bioprosthetic: Homograft Heterograft

آیا بیمار با دریچه مصنوعی قلب اجازه حاملگی دارد؟

WHO III Significantly increased risk of maternal mortality and cardiac & obstetrical care

در صورت دریچه بیوپروستتیک و حاملگی چه اقدامی انجام می‌دهید؟

No anti coagulation, unless Aspirin therapy No anti coagulation, unless Prior thrombosis AF 3-6 m after MVR

دریچه مصنوعی مکانیکال در حاملگی چه خطراتی دارد؟

Valve thrombosis Thromboembolism Death

خانم حامله با دریچه مصنوعی مکانیکال قلب در 3 ماه اول حاملگی (هفته 12-5) چه اقدامی انجام شود؟

ASA (75-100mg) Anticoagulation: Warfarin ≤ 5mg: 2.5 ≤ INR ≤ 3.5 Embriopathy, fetal loss LMWH: anti factor Xa: 0.8-1/2 u/ml UFH: PTT: 2-2.5 fold

خانم حامله با دریچه مکانیکال قلب در سن حاملگی 36-13 هفته چه اقدامی انجام شود؟

ASA (75-100mg) Anticoagulation: Warfarin 2.5 ≤ INR ≤ 3.5 Fetal loss LMWH: anti factor Xa: 0.8-1/2 u/ml LMWH: 1mg/kg/dose/twice daily

خانم حامله با دریچه مکانیکال قلب در سن حاملگی 36 هفته به بعد چه اقدامی انجام شود؟

ASA (75-100mg) Anticoagulation: LMWH: anti factor Xa: 0.8-1/2 u/ml LMWH: 1mg/kg/dose/twice daily

خانم حامله با دریچه مکانیکال قلب در پری پارتوم و پُست پارتوم چه اقدامی انجام شود؟

Discontinue 6h before NVD 4-6h after MVD 6h before C/S 12h after C/S UFH: 1000-1250 u/h PTT: 2-2.5 fold Discontinue 6h before NVD 4-6h after MVD 24-48h therapeutic level 6h before C/S 12h after C/S 48-72h therapeutic level + ASA + Warfarin (5-7 days)

در صورتی که مادر حامله با مصرف وارفارین در جریان لِیبر قرار گیرد چه اقدامی توصیه می‌شود؟

C/S FFP Vit K

در صورتی که مادر حامله با مصرف اِنوکساپارین در جریان لِیبر قرار گیرد چه اقدامی توصیه می‌شود؟

Protamin sulfate NVD or C/S

در صورتی که مادر حامله با مصرف هپارین در جریان لِیبر قرار گیرد چه اقدامی توصیه می‌شود؟

Protamin sulfate NVD or C/S

آیا بیماری دریچه قلب از والدین به فرزند به ارث می‌رسد؟

Genetic factor Mother > father AS

با تشکر فراوان