by Nadine Martel, James Lee, and Philip S. Wells

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Presentation transcript:

by Nadine Martel, James Lee, and Philip S. Wells Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis by Nadine Martel, James Lee, and Philip S. Wells Blood Volume 106(8):2710-2715 October 15, 2005 ©2005 by American Society of Hematology

Flow diagram of study selection. Flow diagram of study selection. ACS indicates acute coronary syndrome; HD, heart disease. Nadine Martel et al. Blood 2005;106:2710-2715 ©2005 by American Society of Hematology

Analysis 1: HIT outcome (RCTs). Analysis 1: HIT outcome (RCTs). Comparison: UFH versus LMWH. There were no LMWH events and 10 UFH events. Test for heterogeneity: χ2 = 0.36; df = 1 (P = .55); I2 = 0%. Test for overall effect: Z = 2.14 (P = .03). ▪ represents the summary OR; vertical line, 95% CI; and ♦, OR and 95% CI. Nadine Martel et al. Blood 2005;106:2710-2715 ©2005 by American Society of Hematology

Analysis 2: HIT outcome (RCTs and prospective studies). Analysis 2: HIT outcome (RCTs and prospective studies). Comparison: UFH versus LMWH; outcome (RCTs and prospective studies). Total events for treatment-LMWH = 1; for control-UFH = 31. Test for heterogeneity: χ2 = 1.18, df = 4(P = .88), I2 = 0%. Test for overall effect: Z = 3/74 (P < .001). Symbols are as in Figure 2. Nadine Martel et al. Blood 2005;106:2710-2715 ©2005 by American Society of Hematology

Analysis 3: thrombocytopenia outcome. Analysis 3: thrombocytopenia outcome. Comparison: UFH versus LMWH; outcome: thrombocytopenia (HIT and non-HIT). Total events for LMWH = 152; total events for UFH = 238. Test for heterogeneity: χ2 = 46.11; df = 9 (P < .001); I2 = 80.5%. Test for overall effect: Z = 1.90 (P = .06). Symbols are as in Figure 2. Nadine Martel et al. Blood 2005;106:2710-2715 ©2005 by American Society of Hematology