Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease  Guillaume Bouguen, Barrett G. Levesque, Brian G. Feagan, Arthur Kavanaugh, Laurent Peyrin–Biroulet, Jean–Frederic Colombel, Stephen B. Hanauer, William J. Sandborn  Clinical Gastroenterology and Hepatology  Volume 13, Issue 6, Pages 1042-1050.e2 (June 2015) DOI: 10.1016/j.cgh.2013.09.006 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Overview of the treat to target concept. According to risk stratification, highly effective disease-modifying therapy should first be administered to high-risk patients. Treatments should then be monitored and adjusted by using a predefined objective target. Clinical Gastroenterology and Hepatology 2015 13, 1042-1050.e2DOI: (10.1016/j.cgh.2013.09.006) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 Schematic representation for a treat-to-target based strategy for CD. On the basis of preliminary experience from RA, proposal algorithm for CD includes careful selection of patients to active treatment, use of MH as the optimal target, and a time frame to assess treatment efficacy. Clinical Gastroenterology and Hepatology 2015 13, 1042-1050.e2DOI: (10.1016/j.cgh.2013.09.006) Copyright © 2015 AGA Institute Terms and Conditions