Growth Factors, Minerals and Vitamins

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Presentation transcript:

Growth Factors, Minerals and Vitamins HEMATOPOIETIC AGENTS Growth Factors, Minerals and Vitamins The short life span of mature blood cells requires their continuous replacement, a process termed hematopoiesis New cell production must be responsive to both basal needs and situations of increased demand

An early sign of deficiency is a megaloblastic anemia VITAMIN B12 Vitamin B12 and folic acid are dietary essentials A deficiency of either vitamin results in defective synthesis of DNA in any cell in which chrosomal replication and division are taking place An early sign of deficiency is a megaloblastic anemia

VITAMIN B12 Cyanocobalamin Hydroxocobalamin Methylcobalamin 5-Deoxyadenosylcobalamin

VITAMIN B12 Metabolic functions The active coenzymes CH3 B12 and Deoxyadensoyl B12 are essential for cell growth and replacation. CH3 B12 is required for the formation of methionine and its derivative S-adenosylmethionine from homocysteine. 5-Deoxyadenosylcobalamin is requred for the isomerization of L-methylmalonyl CoA to succinyl CoA.

FOLIC ACID Metabolic Functions Conversion of homocysteine to methionine (CH3H4PteGlu) Conversion of serine to glycine (H4PteGlu) Synthesis of thymidilate (5,10-CH2H4PteGlu) Histidine metabolism (H4PteGlu) Synthesis of purines Utilization or generation of formate