Endocrine and Metabolic Manifestations of Invasive Fungal Infections and Systemic Antifungal Treatment Michail S. Lionakis, MD, ScD, George Samonis,

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Presentation transcript:

Endocrine and Metabolic Manifestations of Invasive Fungal Infections and Systemic Antifungal Treatment Michail S. Lionakis, MD, ScD, George Samonis, MD, Dimitrios P. Kontoyiannis, MD, MS, ScD Mayo Clinic Proceedings Volume 83, Issue 9, Pages 1046-1060 (September 2008) DOI: 10.4065/83.9.1046 Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE The main pathways of steroidogenesis in the adrenal glands and inhibitory effects of ketoconazole. The principal enzymes inhibited by ketoconazole are shown in yellow, and the main steroid products whose synthesis is decreased by ketoconazole are shown in red. H = hydrogen; HSD = hydroxysteroid dehydrogenase; O = oxygen; OH = hydroxylase; OHD = hydroxy dehydrogenase; SCC = cholesterol side-chain cleavage. Adapted from Hardman JG, Limbird LE, Gilman AG. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006, with permission of McGraw-Hill. Mayo Clinic Proceedings 2008 83, 1046-1060DOI: (10.4065/83.9.1046) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions