Innate Immunity.

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The Immune System.

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Presentation transcript:

Innate Immunity

Other surface protections against pathogen entry: Microbial Antagonism Microbially-produced acids Bacteriocins

Major cellular player: Macrophages & Neutrophils

Inflammation: Bring killing-cells to site of infection Block spread of infectious agent Repair injured tissue

Receptors that help immune system cells recognize pathogens: Non-specific recognition of microbial substances initiates an innate immune response, release of cytokines and chemokines. Receptor/substrate interaction

Mannose-binding lectin (MBL)- pattern recognition receptor

Toll-like Receptors (TLR)

TLRs trigger: cytokines chemokines Cell surface molecules necessary for adaptive immune responses

Complement: a set of blood proteins that, once activated, lead to…

View textbook CD movie 9.2

Classical Pathway activation: Ab binds to microbe surface MB-Lectin Pathway activation: MBL binds to sugars on microbe surface Alternative Pathway activation: Spontaneous cleavage of C3 cascade continues on pathogen surface cascade is inhibited on human cell surface