Course of Immunology - introduction (2016/2017) Marta Sobotková email: marta.sobotkova@fnmotol.cz

Course structure ● Lectures Presence in lectures is obligatory Lectures are held every Tuesday at 8:00-9:40 Small Lecture Hall - Three absences are tolerated, more frequent absences must be based on official certificate and will be solved individually

3.10.2017 Immune system, overview. Phagocytic cells, complement. Communication between cells of immune systems, adhesion molecules, cytokines. Špíšek 10.10.2017 Antigen processing and presentation, HLA I and II class. Šedivá 17.10.2017 Immunity against infection. Adkins 24.10.2017 Specific (adaptive) immunity T and B lymphocytes. Palich - Fučíková 31.10.2017 Immunodeficiency,vaccination. 07.11.2017 Immunity against tumors. 14.11.2017 Immunology of transplantation. Kalina 21.11.2017 Autoimmunity. Immunopathology. Sobotková 28.11.2017 Immunopathological reactions,allergy. Klocperk 05.12.2017 Immunotherapy. Podrazil 12.12.2017 Clinical aspects of immune disorders. Horváth

Course structure ● Seminars - The first seminar and presentation of your thesis are compulsory; the time of other seminars is devoted to self-studying, preparation of seminar thesis and consultations with teachers

Seminar thesis ● groups of 1-3 students ● structure of thesis: 1000 – 2000 words form of an essay briefly & concisely & interestingly Abstract, text and references (literature) are obligatory, subchapters and discussion are recommended ●Term of submission: until 27.10.2017 in the digital form (doc, docx form preffered) - has to be sent to: irena.novakova@lfmotol.cuni.cz

Oral presentations November 23, 30 and December 7 time 8.00-9.40 November 24 and December 1 and 8 - each thesis will be presented verbally - range: 8 minutes Powerpoint presentation (6-10 slides)

Final appraisal ● Presence on lectures ● Seminar thesis: fulfilled / not fulfilled + verbal appraisal (after presentation) ● Verbal examination: 2 out of 50 questions

Evaluation of the essay: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the essay Other comments: Evaluation of the verbal presentation: 3/ Satisfactory graphical layout and style of the presentation

http://imunologie.lf2.cuni.cz/ ● shedules ● presentations (download possible) ● recommended literature, links ● contacts

Citation Most of the patients are hemizygous for 22q11.2, some have defects in various loci on chromosome 10, about 10% of cases are familial (2, 3). Literature / References: 2. DRISCOLL DA, SALVIN J, SELLINGER B, et al. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J Med Genet 1993: 30: 813-7. 3. SEDIVA A, BARTUNKOVA J, ZACHOVA R, et al. Early development of immunity in diGeorge syndrome. Med Sci Monit 2005: 11: 182-7.

Sources Bibliographic databases Clinical sources online

Pubmed – www.pubmed.com

Medscape - www.emedicine.com

Up-to-date – www.uptodate.com

Orphanet – www.orpha.net

Good luck with Your essays and presentations ! Marta Sobotková email: marta.sobotkova@fnmotol.cz