Parallels in antimicrobial peptide mechanisms of action and resistance

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Presentation transcript:

Parallels in antimicrobial peptide mechanisms of action and resistance. Parallels in antimicrobial peptide mechanisms of action and resistance. Key: OM, outer membrane; CW, cell wall; CM, cytoplasmic membrane; CY, cytoplasm; NA, nucleic acid. Specific mechanisms of antimicrobial peptide action are denoted with symbols consistent with Fig. 3. Other symbols used are as follows: ovals, organelles; double helix, nucleic acids; light spheres, inactive peptides; crescents, degraded peptides. Specific examples of mechanisms of action or resistance, listed in parentheses, are representative only and should not be considered exhaustive. Michael R. Yeaman, and Nannette Y. Yount Pharmacol Rev 2003;55:27-55 The American Society for Pharmacology and Experimental Therapeutics