Transport across Plasma Membranes

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Presentation transcript:

Transport across Plasma Membranes

Transport through plasma membranes Passive transport modalities -Simple diffusion: transport through lipid bilayer, transport through channels, Ficks law of diffusion. -Facilitated diffusion: by carriers Differences in diffusion Kinetics between the previous modalities Equivalent Concentration of particles.

Transport through plasma membranes Passive transport modalities -Osmosis: concept of osmotic pressure (Van’t Hoff’s law), Oncotic (Colloid-osmotic) pressure.Osmolarity, osmolality Hydrostatic pressure

Transport through plasma membranes Active transport modalities - Primary active transport (ATP-ase carriers or Pumps) (functions of pumps: Na+/K+ pump, Ca++ pump, H+ pump, H+/K+ pump). - Secondary active transport (Na+ dependent carriers) examples

Transport through plasma membranes Active transport modalities - Vesicular transport: endocytosis, phagocytosis, transcytosis, pinocytosis and exocytosis and its control in secretory cells.-

Active Transport Mechanisms Primary active transport Secondary active transport Vesicular transport

Types of Pumps Na+/K+ pump H+ pump H+/K+ pump Ca++ pump

Phosphorylation & dephosphorylation

Types of Pumps Na+/K+ pump H+ pump H+/K+ pump Ca++ pump

The importance of pumps for cell functions

Secondary Active Transport

Secondary Active Transport Co-transport Counter transport

Vesicular Transport

Formation of vesicles at ER

Endocytosis

Phagocytosis

Receptor mediated endcytosis

Exocytosis

Transcytosis

Control of Transport

Receptors & Enzymes

Receptors & Channels

Receptors & G proteins

Control of Transport and activity of Enzymes

Transport is Controlled by Activation of receptors - Changing activity of enzymes

Control of Exocytosis