Margaretha A. Faber, MD, Vito Sabato, MD, Chris H

Slides:

Advertisements

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.) Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Fatty acids, inflammation, and asthma

Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema Sabine Zeller, MSc, Claudio Rhyner, PhD, Norbert Meyer, MD, Peter.

Reduced TH1/TH17 CD4 T-cell numbers are associated with impaired purified protein derivative–specific cytokine responses in patients with HIV-1 infection

Margaretha A. Faber, MD, PhD, Athina L. Van Gasse, MD, Ine I

Role of the basophil activation test in the diagnosis of local allergic rhinitis Enrique Gómez, PhD, Paloma Campo, MD, PhD, Carmen Rondón, MD, PhD, Esther.

Ibrutinib, a Bruton’s tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis Kaori Mukai, PhD, Nicolas Gaudenzio,

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Fatty acids, inflammation, and asthma

Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing.

Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut Leticia Tordesillas, PhD, Adeeb H. Rahman,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Direct monitoring of basophil degranulation by using avidin-based probes Régis Joulia, PhD, Claire Mailhol, MD, Salvatore Valitutti, MD, Alain Didier,

CD203c expression on human basophils is associated with asthma exacerbation Emiko Ono, MD, PhD, Masami Taniguchi, MD, PhD, Noritaka Higashi, MD, PhD,

Physician needs in health informatics: Just ask the docs

Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions Maria José Torres, MD, PhD,

Peter M. Wolfgram, MD, David B. Allen, MD

Identification of bee venom Api m 1 IgE epitopes and characterization of corresponding mimotopes Abida Zahirović, MPharm, Ana Koren, PhD, Peter Kopač,

Donald W. MacGlashan, MD, PhD, Sarbjit S. Saini, MD

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Roles of arginase variants, atopy, and ozone in childhood asthma

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria Thomas Gentinetta, MSc, Tatjana.

Peanut T-cell epitope discovery: Ara h 1

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population Carlos Blanco, MD, PhD, Florentino Sánchez-García,

Familial hypertryptasemia with associated mast cell activation syndrome Vito Sabato, MD, Els Van De Vijver, MD, PhD, Margo Hagendorens, MD, PhD, Inge.

Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance Lara S. Ford, MD, MPH, Katherine A. Bloom, MD,

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Anaphylaxis caused by hidden soybean allergens in pillows

Casein-related anaphylaxis after use of an Everlast kickboxing glove

Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites Zhikang Peng, MD, Andrew N. Beckett, BSc,

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab Donald W. MacGlashan,

Effect of aging on sputum inflammation and asthma control

Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and.

Pedro Gamboa, MD, PhD, Rosa Sanchez-Monge, PhD, M

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study

Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma Kugathasan Mutalithas, MRCP, Joanne Croudace, PhD, Cristina Guillen,

Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors Mrinmoy Das, MSc, Caroline.

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria Sridharan Soundararajan, PhD, Yoko Kikuchi, DVM, Kusumam Joseph, PhD,

Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,

Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization Edwin H. Kim, MD, J. Andrew Bird, MD, Michael Kulis,

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

Natural history of cow’s milk allergy

Alexander S. Kim, MD, Taylor A. Doherty, MD, Maya R

Primary prevention of asthma and allergy

The Editors' Choice Journal of Allergy and Clinical Immunology

Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,

Presentation transcript:

Clinical relevance of the Hevea brasiliensis lipid transfer protein Hev b 12 Margaretha A. Faber, MD, Vito Sabato, MD, Chris H. Bridts, MT, Ajay Nayak, PhD, Donald H. Beezhold, PhD, Didier G. Ebo, MD, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 6, Pages 1645-1648.e1 (June 2015) DOI: 10.1016/j.jaci.2014.12.1919 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Basophil activation with rHev b 12. Percentages of CD63+ and CD203c++ basophils after stimulation with 5 different concentrations of rHev b 12 in patients with latex allergy and Hev b 12 sensitization (n = 2, red line), patients with latex allergy without Hev b 12 sensitization (n = 3, green line), and 3 healthy control subjects (black line). Journal of Allergy and Clinical Immunology 2015 135, 1645-1648.e1DOI: (10.1016/j.jaci.2014.12.1919) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Basophil selection and activation: BAT plot in a patient with latex allergy and sensitization to rHev b 12 and nCan s 3. A and B, Detection of basophils by using side scatter (SSC) and gating out IgEhigh and CD203c+ cells. C, Within this gate, numbers of activated basophils expressing CD63 were measured. Stimulation with activation buffer served as a negative control for spontaneous CD63 expression. D, Stimulation with anti-human IgE (10 μg/mL, BD Biosciences) was used as a positive control. E-H, Basophil stimulation with NRL extract (1 μg/mL), rHev b 12 (0.1 μg/mL), nCan s 3 (0.1 μg/mL), and nPru p 3 (0.1 μg/mL), respectively. Journal of Allergy and Clinical Immunology 2015 135, 1645-1648.e1DOI: (10.1016/j.jaci.2014.12.1919) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions