by Paolo Strati, and Tait D. Shanafelt Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification by Paolo Strati, and Tait D. Shanafelt Blood Volume 126(4):454-462 July 23, 2015 ©2015 by American Society of Hematology

General approach to the workup of lymphocytosis. General approach to the workup of lymphocytosis. BM, bone marrow; CMV, cytomegalovirus; CTD, connective tissue disease; EBV, Epstein-Barr virus; FL, follicular lymphoma; HCL, hairy cell leukemia; HTLV, human T-lymphotropic virus; LGL, large-granular leukemia; LN, lymph nodes; LPL, lymphoplasmacytic lymphoma; MCL, mantle cell lymphoma; MF, mycosis fungoides; T-PLP, T prolymphocytic leukemia; SMZ, splenic marginal zone lymphoma; T-leu, T-cell leukemia; VZV, varicella zoster virus. Paolo Strati, and Tait D. Shanafelt Blood 2015;126:454-462 ©2015 by American Society of Hematology

Distribution of clonal CLL-like B-cell count in published studies. Distribution of clonal CLL-like B-cell count in published studies. Two main entities can be identified: low-count MBL, usually detected in general population studies, and high-count MBL, usually detected in series of patients referred for lymphocytosis. Reprinted with permission from Rawstron et al.29 Paolo Strati, and Tait D. Shanafelt Blood 2015;126:454-462 ©2015 by American Society of Hematology

Management of early-stage CLL and SLL Management of early-stage CLL and SLL. B2M, β-2-microglobulin; IgG, immunoglobulin G; IVIG, intravenous immunoglobulins; MX, mammogram; PCV, pneumococcus vaccine; PS, performance status; Tdap, tetanus diphtheria, acellular pertussis. Management of early-stage CLL and SLL. B2M, β-2-microglobulin; IgG, immunoglobulin G; IVIG, intravenous immunoglobulins; MX, mammogram; PCV, pneumococcus vaccine; PS, performance status; Tdap, tetanus diphtheria, acellular pertussis. Paolo Strati, and Tait D. Shanafelt Blood 2015;126:454-462 ©2015 by American Society of Hematology