Does Reduced Creatine Synthesis Protect against Statin Myopathy?

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

One Strike against Low-Carbohydrate Diets

Dual regulation of the LDL receptor—Some clarity and new questions

The ART of Lowering Ceramides

Metabolic Acceleration in Human Evolution

Making Muscle or Mitochondria by Selective Splicing of PGC-1α

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Interleukins and Atherosclerosis: A Dysfunctional Family Grows

Something Old, Something New, Something Borrowed …

Homing in on bile acid physiology

Can Your Microbiome Tell You What to Eat?

Volume 9, Issue 2, Pages (August 2011)

Serotonin and the Orchestration of Energy Balance

The Evolution of the Algorithms for Collective Behavior

Volume 24, Issue 3, Pages (September 2016)

mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis

Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Autophagy: Paying Charon's Toll

Fingered for a Fat Fate Cell Metabolism

Gal3 Links Inflammation and Insulin Resistance

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

Volume 21, Issue 4, Pages (April 2015)

Volume 17, Issue 4, Pages (April 2013)

Is Predisposition to NAFLD and Obesity Communicable?

APOC3, Coronary Disease, and Complexities of Mendelian Randomization

CHD7 in Charge of Neurogenesis

Jelena Kolic, James D. Johnson Cell Metabolism

The CAMplexities of Central Ghrelin

Treating Obesity? It's in the Bag!

Life Is Short, if Sweet Cell Metabolism

Adiponectin Sparks an Interest in Calcium

One Strike against Low-Carbohydrate Diets

Making Biological Sense of GWAS Data: Lessons from the FTO Locus

Eukaryotic Transcription Activation: Right on Target

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

Branching Out for Detection of Type 2 Diabetes

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Autophagy Works Out Cell Metabolism

Volume 143, Issue 6, (December 2010)

Proteins in Plant Brassinosteroid Signaling

Exercise Controls Non-Coding RNAs

MicroRNA-155 Function in B Cells

An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism

Protein nutrition as therapy for a genetic disorder of bone?

Volume 35, Issue 6, Pages (December 2011)

Volume 22, Issue 4, Pages (April 2018)

Homing in on bile acid physiology

Macrophage Metabolism Shapes Angiogenesis in Tumors

Volume 24, Issue 1, Pages 7-8 (July 2016)

“AcCoA”lade for Energy and Life Span

Many Roads Lead to the Lipid Droplet

Angiotensin in the Kidney: A Key to Understanding Hypertension?

AMPK and p53 help cells through lean times

Estrogens and Obesity: Is It All in Our Heads?

Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse

Presentation transcript:

Does Reduced Creatine Synthesis Protect against Statin Myopathy? Kevin D. Ballard, Paul D. Thompson Cell Metabolism Volume 18, Issue 6, Pages 773-774 (December 2013) DOI: 10.1016/j.cmet.2013.11.012 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Mechanism by which Reduced GATM Activity Reduces Statin Myopathy Risk Simvastatin reduced GATM transcriptional expression, and this effect was associated with a reduced incidence of statin myopathy (Mangravite et al., 2013). Reduced intramuscular Cr may protect against statin-induced myopathy. GATM, glycine amidinotransferase; CP, creatine phosphate; Cr, creatine. Cell Metabolism 2013 18, 773-774DOI: (10.1016/j.cmet.2013.11.012) Copyright © 2013 Elsevier Inc. Terms and Conditions