Measuring Therapeutic Response in Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical.

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Presentation transcript:

Measuring Therapeutic Response in Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group Report Steven Z. Pavletic, Paul Martin, Stephanie J. Lee, Sandra Mitchell, David Jacobsohn, Edward W. Cowen, Maria L. Turner, Gorgun Akpek, Andrew Gilman, George McDonald, Mark Schubert, Ann Berger, Peter Bross, Jason W. Chien, Daniel Couriel, J.P. Dunn, Jane Fall-Dickson, Ann Farrell, Mary E.D. Flowers, Hildegard Greinix, Steven Hirschfeld, Lynn Gerber, Stella Kim, Robert Knobler, Peter A. Lachenbruch, Frederick W. Miller, Barbara Mittleman, Esperanza Papadopoulos, Susan K. Parsons, Donna Przepiorka, Michael Robinson, Michael Ward, Bryce Reeve, Lisa G. Rider, Howard Shulman, Kirk R. Schultz, Daniel Weisdorf, Georgia B. Vogelsang Biology of Blood and Marrow Transplantation Volume 12, Issue 3, Pages 252-266 (March 2006) DOI: 10.1016/j.bbmt.2006.01.008 Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Skin manifestations assessed for response in chronic GVHD. A, Erythematous papular rash. B, Erythematous rash with papules and small scaly plaques. C, Dermal sclerosis. Skin is thickened, with decreased mobility to pinching but without adherence to underlying tissues. D, Subcutaneous sclerosis. Skin is hidebound, fixed to underlying tissues and cannot be pinched. Ulcers are present. Biology of Blood and Marrow Transplantation 2006 12, 252-266DOI: (10.1016/j.bbmt.2006.01.008) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Oral manifestations assessed for response in chronic GVHD. A, Moderate erythema of vermilion lip. Labial mucosa shows severe erythema. B, Area of sheetlike lichenoid hyperkeratosis is present inside commissure. C, Ulcer with pseudomembranous fibrin exudates surrounded by severe erythema. D, Numerous vesicle-like mucoceles are seen at center of the palate, with patches of lichenoid hyperkeratosis and moderate erythematous changes. Biology of Blood and Marrow Transplantation 2006 12, 252-266DOI: (10.1016/j.bbmt.2006.01.008) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions