Cancer: Inappropriate Expression of Stem Cell Programs?

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Cancer: Inappropriate Expression of Stem Cell Programs? Yingzi Wang, Scott A. Armstrong Cell Stem Cell Volume 2, Issue 4, Pages 297-299 (April 2008) DOI: 10.1016/j.stem.2008.03.014 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 An ESC-like Program in Epithelial Cancer Stem Cells (A) Certain adult tissue stem cells share a transcriptional program with ESCs, termed an ESC-like program. Comparing the mouse and human ESC-like programs reveals 335 overlapping genes. The overlapping set is used to define a “core” ESC-like program, a large subset of which has been identified as c-Myc targets. (B) c-Myc expression can activate the ESC-like program in keratinocytes and lead to the development of a tumor-forming population, possibly by inducing a cancer stem cell population. Cell Stem Cell 2008 2, 297-299DOI: (10.1016/j.stem.2008.03.014) Copyright © 2008 Elsevier Inc. Terms and Conditions