Effects of Renal Replacement Therapy in Patients Receiving Extracorporeal Membrane Oxygenation: A Meta-Analysis Seon-Sook Han, MD, PhD, Hyun Jung Kim,

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Effects of Renal Replacement Therapy in Patients Receiving Extracorporeal Membrane Oxygenation: A Meta-Analysis Seon-Sook Han, MD, PhD, Hyun Jung Kim, MPH, PhD, Seung Joon Lee, MD, PhD, Woo Jin Kim, MD, PhD, Youngi Hong, MD, Hui- Young Lee, MD, Seo-Young Song, MD, PhD, Hae Hyuk Jung, MD, PhD, Hyeong Sik Ahn, MD, PhD, Il Min Ahn, Hyunjeong Baek, MD, PhD The Annals of Thoracic Surgery Volume 100, Issue 4, Pages 1485-1495 (October 2015) DOI: 10.1016/j.athoracsur.2015.06.018 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow diagram of study method. (ECMO = extracorporeal membrane oxygenation; RRT = renal replacement therapy.) The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Inpatient mortality rates of extracorporeal membrane oxygenation (ECMO) based on use of renal replacement therapy (RRT). Solid lines represent 95% confidence intervals (CIs) of effect size (ES) estimates for individual studies, box sizes represent the study weighing, dashed lines represent combined ES, and diamonds represent 95% CIs for overall ES. (ECPR = extracorporeal cardiopulmonary resuscitation; RRT = renal replacement therapy.) The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Inpatient mortality according to mortality rates of extracorporeal membrane oxygenation (ECMO) without renal replacement therapy. We sorted studies into mortality of control group. Solid lines represent 95% confidence interval (CI) of risk ratio (RR) estimates for individual studies, box sizes represent the study weighing, dashed lines represent combined RR, and diamonds represent 95% CI for pooled RR. The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Inpatient mortality according to subgroups of age and indications for extracorporeal membrane oxygenation (ECMO). (A) Indications for ECMO. (B) Age while receiving ECMO. We sorted studies into mortality of control group. Solid lines represent 95% confidence interval (CI) of risk ratio (RR) estimates for individual studies, box sizes represent the study weighing, dashed lines represent combined RR, and diamonds represent 95% CI for polled RR. (ECPR = extracorporeal cardiopulmonary resuscitation.) The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Inpatient mortality according to subgroups of age and indications for extracorporeal membrane oxygenation (ECMO). (A) Indications for ECMO. (B) Age while receiving ECMO. We sorted studies into mortality of control group. Solid lines represent 95% confidence interval (CI) of risk ratio (RR) estimates for individual studies, box sizes represent the study weighing, dashed lines represent combined RR, and diamonds represent 95% CI for polled RR. (ECPR = extracorporeal cardiopulmonary resuscitation.) The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Inpatient mortality rates of well-matched studies and renal replacement therapy (RRT) initiation times. Case-matched studies (A) according to the RRT starting time (B). Solid lines represent 95% confidence intervals (CIs) of risk ratio (RR) estimates for individual studies, box sizes represent the study weighing, and diamonds represent 95% CI for pooled RR in subgroups. (RRT = renal replacement therapy.) The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Appendix Figure 1 The Annals of Thoracic Surgery 2015 100, 1485-1495DOI: (10.1016/j.athoracsur.2015.06.018) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions