Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

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Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients Marta Michalska-Kasiczak, Amirhossein Sahebkar, Dimitri P. Mikhailidis, Jacek Rysz, Paul Muntner, Peter P. Toth, Steven R. Jones, Manfredi Rizzo, G. Kees Hovingh, Michel Farnier, Patrick M. Moriarty, Vera A. Bittner, Gregory Y.H. Lip, Maciej Banach International Journal of Cardiology Volume 178, Pages 111-116 (January 2015) DOI: 10.1016/j.ijcard.2014.10.118 Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Flow diagram of the study selection process. International Journal of Cardiology 2015 178, 111-116DOI: (10.1016/j.ijcard.2014.10.118) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Forest plots summarizing the meta-analysis of observational studies comparing plasma vitamin D levels between myalgic and asymptomatic subjects. International Journal of Cardiology 2015 178, 111-116DOI: (10.1016/j.ijcard.2014.10.118) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Funnel plots detailing publication bias in the studies selected for analysis. Trim and fill method was used to impute for potentially missing studies. Open circles represent observed published studies; closed circles represent imputed unpublished studies. Open and closed diamonds represent observed and imputed effect size, respectively. International Journal of Cardiology 2015 178, 111-116DOI: (10.1016/j.ijcard.2014.10.118) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions