Efficacy and safety of dupilumab for the treatment of adult atopic dermatitis: A meta- analysis of randomized clinical trials Yue Han, MD, Yuxin Chen,

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Efficacy and safety of dupilumab for the treatment of adult atopic dermatitis: A meta- analysis of randomized clinical trials Yue Han, MD, Yuxin Chen, PhD, Xiaochun Liu, MD, Jingxi Zhang, MD, Huichun Su, MD, He Wen, MD, Wei Li, MD, PhD, Xu Yao, MD, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 3, Pages 888-891.e6 (September 2017) DOI: 10.1016/j.jaci.2017.04.015 Copyright © 2017 Terms and Conditions

Fig 1 Meta-analysis of efficacy outcomes of 7 RCTs with dupilumab- and placebo-treated patients with AD. A, The EASI score. B, The IGA score. C, Pruritus numerical-rating scale (NRS) score. D, Body surface area (BSA) score. Horizontal lines stand for 95% Cls of the RR estimates. Green dots represent the SMD. Blue dots represent the RR, and diamonds represent the meta-analysis summary effect estimate. Journal of Allergy and Clinical Immunology 2017 140, 888-891.e6DOI: (10.1016/j.jaci.2017.04.015) Copyright © 2017 Terms and Conditions

Fig E1 Study selection process. We collected 167 potentially relevant studies, of which 7 were included in the meta-analysis. Journal of Allergy and Clinical Immunology 2017 140, 888-891.e6DOI: (10.1016/j.jaci.2017.04.015) Copyright © 2017 Terms and Conditions

Fig E2 A, Risk of bias summary for each included study. B, Begg funnel plot. Studies with larger scale have been spread around the average, and publications with smaller scale were plodded evenly on each side of the average. Deviation from such funnel-like distribution is able to point out the bias of the studies. Both the funnel plot and Egger test showed no evidence of bias in the publication. Journal of Allergy and Clinical Immunology 2017 140, 888-891.e6DOI: (10.1016/j.jaci.2017.04.015) Copyright © 2017 Terms and Conditions

Fig E3 Galbraith radial plot. The figure shows the contribution of results from the patient groups treated with different doses of dupilumab in the different studies to the heterogeneity of efficacy of treatment. The following studies were included: phase IIb 300qw (1), phase IIb 200q2w (2), phase IIb 300q2w (3), phase IIb 100q4w (4), phase IIb 300q4w (5), M4 (6), M12 (7), C4 (8), SOLO1 300q2w (9), SOLO1 300qw (10), SOLO2 300q2w (11), and SOLO2 300qw (12). The group receiving 100 mg every 4 week (100q4w) in phase IIb study was found to be the main cause of the heterogeneity. Journal of Allergy and Clinical Immunology 2017 140, 888-891.e6DOI: (10.1016/j.jaci.2017.04.015) Copyright © 2017 Terms and Conditions

Fig E4 Forest plot of rate of AEs, SAEs, and study discontinuation in 7 RCTs. A, AE rates and RR of AE rates between dupilumab- and placebo-treated patients. B, SAE rates and RR of SAE rates between dupilumab- and placebo-treated patients. C, Rates of study discontinuation and RR of study discontinuation between dupilumab- and placebo-treated patients. Diamonds stand for the meta-analysis summary effect estimate. Blue dots represent the RR, and horizontal lines represent 95% CIs of the RR estimates. Journal of Allergy and Clinical Immunology 2017 140, 888-891.e6DOI: (10.1016/j.jaci.2017.04.015) Copyright © 2017 Terms and Conditions