Restoring Balance: Paraneoplastic Cerebellar Degeneration

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Presentation transcript:

Restoring Balance: Paraneoplastic Cerebellar Degeneration Joshua P. Klein, MD, PhD, Daniel G. Stover, MD, Geoffrey R. Oxnard, MD, Bruce D. Levy, MD, Joseph Loscalzo, MD, PhD The American Journal of Medicine Volume 130, Issue 3, Pages e85-e87 (March 2017) DOI: 10.1016/j.amjmed.2016.09.035 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 PET-CT images of the chest and head. (A) 18F-fluorodeoxyglucose PET image of the chest and head demonstrates multiple 18F-fluorodeoxyglucose–avid masses in the mid and anterior chest (black arrow). (B) Representative slices of fused PET-CT images show the 18F-fluorodeoxyglucose–avid right upper lobe lung mass and hilar and mediastinal lymph nodes. (C) Fused PET-CT image of the brain demonstrates reduced uptake in the cerebellar cortices (white arrows), suggestive of hypometabolism. The American Journal of Medicine 2017 130, e85-e87DOI: (10.1016/j.amjmed.2016.09.035) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Lymph node biopsy specimen. High-power view of 4R lymph node biopsy (hematoxylin-eosin) demonstrates the lymph node replaced with sheets of small round tumor cells with a high nucleus to cytoplasm ratio, hyperchromatic nuclei, and prominent nuclear molding. Necrosis and characteristic crush artifact also were present. The American Journal of Medicine 2017 130, e85-e87DOI: (10.1016/j.amjmed.2016.09.035) Copyright © 2016 Elsevier Inc. Terms and Conditions