Effects of Oral Branched-Chain Amino Acid Granules on Event-Free Survival in Patients With Liver Cirrhosis  Yasutoshi Muto, Shunichi Sato, Akiharu Watanabe, Hisataka Moriwaki, Kazuyuki Suzuki, Akinobu Kato, Masahiko Kato, Teiji Nakamura, Kiyohiro Higuchi, Shuhei Nishiguchi, Hiromitsu Kumada  Clinical Gastroenterology and Hepatology  Volume 3, Issue 7, Pages 705-713 (July 2005) DOI: 10.1016/S1542-3565(05)00017-0 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Details of analysis. ITT, intent-to-treat; Diet, diet therapy; BCAA, BCAA supplementation; FAS, full analysis set. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Kaplan-Meier estimates of event-free survival in the 2 study groups. Events for the primary end point were aggravation of hepatic failure (ascites, peripheral edema, hepatic encephalopathy, and jaundice), rupture of esophageal or gastric varices, development of liver cancer, and death due to any cause. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Kaplan-Meier estimates of the proportion of patients without aggravation of hepatic failure (ascites, peripheral edema, hepatic encephalopathy, and jaundice) in the 2 study groups. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 4 Kaplan-Meier estimates of event-free survival in the 2 study groups with HCV-positive liver cirrhosis. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 5 Kaplan-Meier estimates of event-free survival in the 2 study groups with serum BTR less than 4.0 at entry. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 6 Serum albumin concentration in BCAA group (closed circles) and diet group (closed squares). Data are represented as means and standard errors. The P value of repeated measures analysis of variance is reported. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 7 General health perception scores of the Short Form-36 questionnaire for health-related QOL in BCAA group (closed columns) and diet group (open columns). Data are represented as means and standard errors. The P value of repeated measures analysis of variance is reported. Clinical Gastroenterology and Hepatology 2005 3, 705-713DOI: (10.1016/S1542-3565(05)00017-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions