A contemporary analysis of pulmonary hypertension in patients undergoing mitral valve surgery: Is this a risk factor? Daniel H. Enter, MD, Anthony Zaki,

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A Contemporary Analysis of Pulmonary Hypertension in Patients Undergoing Mitral Valve Surgery: Is this a Risk Factor? Thank you to the society and panel.

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A contemporary analysis of pulmonary hypertension in patients undergoing mitral valve surgery: Is this a risk factor? Daniel H. Enter, MD, Anthony Zaki, BS, Brett F. Duncan, MD, Jane Kruse, RN, BSN, Adin-Cristian Andrei, PhD, Zhi Li, MS, S. Chris Malaisrie, MD, Sanjiv J. Shah, MD, James D. Thomas, MD, Patrick M. McCarthy, MD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 5, Pages 1288-1299 (May 2016) DOI: 10.1016/j.jtcvs.2015.12.063 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Kaplan-Meier survival estimates by pulmonary hypertension (PHT) classification (none, moderate, severe, extreme). The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1288-1299DOI: (10.1016/j.jtcvs.2015.12.063) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Standardized differences in: (A) baseline covariates; and (B) Kaplan-Meier survival estimates in PS-matched analyses for severe versus no PHT. PS, Propensity score; Hx, history; CAD, coronary artery disease; CABG, coronary artery bypass graft; MI, myocardial infarction; NYHA, New York Heart Association; Afib, atrial fibrillation; MV, mitral valve; SAM, systolic anterior motion. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1288-1299DOI: (10.1016/j.jtcvs.2015.12.063) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Standardized differences in: (A) baseline covariates; and (B) Kaplan-Meier survival estimates in propensity score–matched analyses for extreme versus no PHT. PS, Propensity score; Hx, history; CAD, coronary artery disease; CABG, coronary artery bypass graft; MI, myocardial infarction; NYHA, New York Heart Association; Afib, atrial fibrillation; MV, mitral valve; SAM, systolic anterior motion. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1288-1299DOI: (10.1016/j.jtcvs.2015.12.063) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Standardized differences in: (A) baseline covariates; and (B) Kaplan-Meier survival estimates in PS-matched analyses by concurrent TVS status in patients with PHT undergoing MVS. PS, Propensity score; Hx, history; CAD, coronary artery disease; CABG, coronary artery bypass graft; MI, myocardial infarction; NYHA, New York Heart Association; Afib, atrial fibrillation; TVS, tricuspid valve surgery. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1288-1299DOI: (10.1016/j.jtcvs.2015.12.063) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Smooth hazard rate estimates for baseline pulmonary artery systolic pressure (as a continuous variable) and corresponding 95% confidence intervals in (A) unadjusted and (B) covariate-adjusted models. A baseline pulmonary artery systolic pressure value of 10 mm Hg serves as the reference point. COPD, Chronic obstructive pulmonary disorder; NYHA, New York Heart Association. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1288-1299DOI: (10.1016/j.jtcvs.2015.12.063) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Kaplan-Meier estimates in propensity-score matched groups: severe group (Severe) versus no PHT (No). The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1288-1299DOI: (10.1016/j.jtcvs.2015.12.063) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions