Macrolactamization of Glycosylated Peptide Thioesters by the Thioesterase Domain of Tyrocidine Synthetase Hening Lin, Desiree A. Thayer, Chi-Huey Wong,

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Presentation transcript:

Macrolactamization of Glycosylated Peptide Thioesters by the Thioesterase Domain of Tyrocidine Synthetase Hening Lin, Desiree A. Thayer, Chi-Huey Wong, Christopher T. Walsh Chemistry & Biology Volume 11, Issue 12, Pages 1635-1642 (December 2004) DOI: 10.1016/j.chembiol.2004.09.015 Copyright © 2004 Elsevier Ltd Terms and Conditions

Figure 1 Synthesis of Glycosylated Amino Acids and Incorporation into Linear Peptidyl-S-NAC Thioesters via Solid-Phase Peptide Synthesis Chemistry & Biology 2004 11, 1635-1642DOI: (10.1016/j.chembiol.2004.09.015) Copyright © 2004 Elsevier Ltd Terms and Conditions

Figure 2 Tyc Syn TE-Catalyzed Head-to-Tail Cyclization to Produce Tyrocidine and Glycosyl-Tyrocidine Variants, with Ser7(β-D-Glc) Shown as an Example Chemistry & Biology 2004 11, 1635-1642DOI: (10.1016/j.chembiol.2004.09.015) Copyright © 2004 Elsevier Ltd Terms and Conditions