The association of uterine cervical microbiota with an increased risk for cervical intraepithelial neoplasia in Korea H.Y. Oh, B.-S. Kim, S.-S. Seo,

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The association of uterine cervical microbiota with an increased risk for cervical intraepithelial neoplasia in Korea H.Y. Oh, B.-S. Kim, S.-S. Seo, J.-S. Kong, J.-K. Lee, S.-Y. Park, K.-M. Hong, H.-K. Kim, M.K. Kim Clinical Microbiology and Infection Volume 21, Issue 7, Pages 674.e1-674.e9 (July 2015) DOI: 10.1016/j.cmi.2015.02.026 Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Comparison of the cervical microbiota of women at the species level using heat-map analysis. The relative abundance of each species was represented by a colour; red indicates a high proportion and blue indicates a low abundance. Hierarchical clustering of the cervical microbiota was performed using the Spearman's correlation. Clinical Microbiology and Infection 2015 21, 674.e1-674.e9DOI: (10.1016/j.cmi.2015.02.026) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 The distribution of four species (Gardnerella vaginalis, Atopobium vaginae, Lactobacillus iners and Lactobacillus crispatus). (a) Area distribution for the relative abundance of four species according to the score of the risky microbial pattern (red, G. vaginalis; orange, A. vaginae; yellow, L. iners; green, L. crispatus). (b) Box plots show a significant difference in the relative abundance of each species between the tertiles of the risky pattern score; (a) p < 0.001, (b) p < 0.001, (c) p = 0.0361, (d) p < 0.001 in the Kruskal–Wallis rank test. Clinical Microbiology and Infection 2015 21, 674.e1-674.e9DOI: (10.1016/j.cmi.2015.02.026) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Quantitative real-time PCR assay of Atopobium vaginae and Lactobacillus crispatus. Log of the ratio of A. vaginae and L. crispatus provided from pyrosequencing (the relative abundances) (a) and real-time PCR (equivalent/μL) (b). A Spearman's rank correlation test was performed for measuring the statistical dependence between two variables; rank correlation coefficient = 0.868, p < 0.001. The p value was from the Wilcoxon rank-sum test for controls and women with cervial intraepithelial neoplasia (CIN). Clinical Microbiology and Infection 2015 21, 674.e1-674.e9DOI: (10.1016/j.cmi.2015.02.026) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions