Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia A. Gradíssimo Oliveira, C. Delgado,

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Fig. 2. Three cervical screening strategies to detect CIN2+/CIN3+

Fig. 1. Flowchart of inclusion and exclusion criteria of the study population.ASC-US, atypical squamous cells of undetermined significance; CIN, cervical.

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Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia A. Gradíssimo Oliveira, C. Delgado, N. Verdasca, Â. Pista Clinical Microbiology and Infection Volume 19, Issue 10, Pages E447-E450 (October 2013) DOI: 10.1111/1469-0691.12233 Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Physical status of viral DNA from (a) human papillomavirus (HPV) type 16 according to cytology; (b) HPV 16 according to histology; (c) HPV 18 according to cytology; and (d) HPV 18 according to histology. Data are presented with standard error bars. NILM, normal cytology; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; ICC, cervical carcinoma, including adenocarcinoma; CIN, cervical intraepithelial neoplasia grade 1–3. Clinical Microbiology and Infection 2013 19, E447-E450DOI: (10.1111/1469-0691.12233) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Comparison of human papillomavirus (HPV) type 16 (a) and HPV 18 (b) E2/E6 ratio according to the different histological categories. Data are presented as T-plots, representing the 5th and 95th centiles. Normal, normal histology; CIN, cervical intraepithelial neoplasia grade 1–3; ICC, cervical carcinoma, including adenocarcinoma. Clinical Microbiology and Infection 2013 19, E447-E450DOI: (10.1111/1469-0691.12233) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions