Biomarker-Driven Management of Sepsis and Antibiotics Evidence and Perspectives.

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Presentation transcript:

Biomarker-Driven Management of Sepsis and Antibiotics Evidence and Perspectives

Sepsis and Septic Shock

Current Challenges in Sepsis

Biomarkers in Sepsis

Diagnostic Criteria for Sepsis

Challenges in Diagnosing Sepsis

Lactate

Elevated Lactate Predicts Mortality

Cytokines

Cytokine Concentrations at Presentation to the ED

C-Reactive Protein

Procalcitonin

PCT Kinetics Provide Important Information on Prognosis of Sepsis Patients

Diagnostic Accuracy of PCT Compared With Other Biomarkers Used In Sepsis

Adding PCT Results to Clinical Assessment Improves Accuracy of Early Clinical Diagnosis of Sepsis

Mortality and PCT Kinetics Over 72 Hours

Role of Nurses in Sepsis Care

Patient Case Examples

Sepsis Protocol Implementation

Sepsis Protocol Implementation (cont)

Sepsis Protocol Implementation (cont)

Goals of Antibiotic Stewardship Programs

2016 Guidelines for Implementing an ASP

Patient Case

Patient Case 2 Hours Later