PREVALENCE OF HIGH RISK FOR TYPE2 DIABETES IN CENTRAL SPAIN

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Presentation transcript:

PREVALENCE OF HIGH RISK FOR TYPE2 DIABETES IN CENTRAL SPAIN 11th Meeting of the Mediterranean Group for the Study of Diabetes Malta, April 23-26, 2009 Rafael Gabriel Hospital Universitario la Paz, Madrid

Prof. Jaakko Tuomilehto DIABETES IN EUROPE: PREVENTION USING LIFESTYLE, PHYSICAL ACTIVITY AND NUTRITIONAL INTERVENTION (DE-PLAN) EUROPEAN Project : 25 centers, 17 countries Prof. Jaakko Tuomilehto

DE-PLAN STUDY CENTRAL-SPAIN (Screening Phase; n=3.007) Burgos Avila Madrid Toledo MADRID: COORDINATING CENTER CENTRAL LAB.

DE-PLAN PRIMARY OBJECTIVES: To detect high risk individuals for T2D in the general adult population (screening phase) Feasibility & effectiveness of lifestyle interventions (diet & physical activity) for primary prevention of T2D in high risk individuals (intervention phase)

DE-PLAN STUDY DESIGN

FINDRISC 8 questions about: age, BMI, waist, physical activity, diet, hypertension, history of high glucose values, family history of diabetes Predicted 10-year diabetes risk with 78% sensitivity and 77% specificity Lindström et al. Diabetes Care 2003;26:725-31.

DE-PLAN CENTRAL-SPAIN Study population: (n=3.007; 45-70 years): Two random samples: 1.026 subjects from the general population of Madrid 1.981 subjects from Primary Care registries

HIGH RISK FOR T2D (FINDRISC >14) IN SUBJECTS 45-70 YEARS IN SPAIN MALES 24.7% 16.7% FEMALES 33.6% 19.8% ALL 28.6% 18.4% Primary Care (n=1.981) General population (n=1.026)

HIGH-RISK OF T2D BY AGE, SEX AND SETTING General pop. Primary Care

HIGH-RISK OF T2D BY BMI General pop. Primary Care

WAIST AND HIGH-RISK OF T2D General pop. Primary Care

OGTT IN THE GENERAL POPULATION Population-based random sample Diabetes (FBG & Rx) 210 n: 2000 OGTT FINDRISK POSITIVE N: 800 FINDRISK NEGATIVE N: 1200 IGT: 80 IFBG: 390 NGT: 190 DIAB: 140 IGT: 100 IFBG: 160 NGT: 920 DIAB: 20 Known Diabetes: 210/2210 = 9.5% Unknown Diabetes: 160/2000 = 8.0% Impaired Glucose Tolerance:180/2000= 8.1%

OGTT IN PRIMARY CARE (OGTT in high risk subjects) 100% 16% 19% 48% 17%