Science Starter **Take out Action Potential Article** What is it called when molecules enter/exit a cell? Which ion moves first in an action potential (sodium, potassium, or calcium)? Can an action potential move backwards? (Why or why not?) What is the cause of Epilepsy? What do you think is the difference between a Schedule 1 drug and a Schedule 2 drugs? https://www.youtube.com/watch?v=SdUUP2pMmQ4

Drug Schedules Schedule 1: Schedule 2: Heroin Lysergic acid diethylamide (LSD) Marijuana (cannabis) 3,4- methylenedioxymethamph etamine (ecstasy) Methaqualone Peyote Schedule 2: Vicodin Cocaine Methamphetamine Methadone meperidine (Demerol) Oxycodone (OxyContin) Fentanyl Adderall and Ritalin

Exit Quiz Place the following images in the correct order & describe what happens in each of these steps A B https://youtu.be/SdUUP2pMmQ4?t=1m20s INSIDE CELL C

Today’s Agenda Science Starter The Synapse Mouse Party War on Drugs Article Exit Quiz

Unit 3: The Nervous System Objective 3.3 Synapse & Nerve Impulse

I. The Synapse Synapse - junction between two communicating neurons Nerve pathway - nerve impulse travels from neuron to neuron Order of Signal Dendrite → cell body → along axon  synapse (gap) → dendrite

I. The Synapse To complete the signal, a NEUROTRANSMITTER is released at the gap to signal the next neuron. Receptors on the dendrite receive the chemical message

II. Neurotransmitters Excitatory - increase membrane permeability, increases chance for threshold to be achieved Inhibitory - decrease membrane permeability, decrease chance for threshold to be achieved

https://www.youtube.com/watch?v=mItV4rC57kM

III. Types of Neurotransmitters Acetylcholine: excitatory (stimulates muscle contraction) GABA: inhibitory (reduces post-synaptic activity) Monoamines: Norepinephrine & Dopamine (sense of feeling good, low levels = depression) Serotonin: mood & sleepiness

Endorphins Produced during exercise, excitement, pain, love and they resemble the opiates (heroin, morphine, etc.) in their abilities to produce a feeling of well-being.

Mouse Party Extension Assignment If you are done filling out the notes on “Mouse Party” then do the following: Pick one of the drugs that you studied in “Mouse Party” and google “__________ medical uses” Write on a separate sheet of paper what the drug is, what it is being used for, and why they are using it for that treatment (1 paragraph)

War on Drugs Article Read the War on Drugs Article for homework Find 5 statistics within the article that are either shocking, disturbing, unbelievable, tough to believe Highlight these and be ready to talk about them in class tomorrow

Exit Quiz 2. The substance released at axonal terminals that send the nerve impulse from one neuron to another neuron is called a: A. hormone B. neurotransmitter C. cholinesterase D. none of the above 1. At the synapse, the nerve impulse travels from A. Post synaptic to presynaptic membrane B. Presynaptic to postsynaptic membrane C. The neurotransmitters to the vesicles D. Calcium channels to the membrane receptors 3. Which letter points to the postsynaptic neuron?