Mitigating the Safety Risks of Drugs With a Focus on Opioids: Are Risk Evaluation and Mitigation Strategies the Answer?  Marta J. Brooks, PharmD  Mayo Clinic Proceedings  Volume 89, Issue 12, Pages 1673-1684 (December 2014) DOI: 10.1016/j.mayocp.2014.09.003 Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Overdose deaths involving opioid analgesics, cocaine, and heroin, United States, 1999-2010. Not all overdose deaths specify the drug(s) involved, and a death may involve more than one specific substance. The increase in 2005-2006 in opioid deaths is related to nonpharmaceutical fentanyl.12 ∗Heroin includes opium. Data from the Centers for Disease Control and Prevention.13 Mayo Clinic Proceedings 2014 89, 1673-1684DOI: (10.1016/j.mayocp.2014.09.003) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions