ETV6-NTRK3—Trk-ing the primary event in human secretory breast cancer

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ETV6-NTRK3—Trk-ing the primary event in human secretory breast cancer David M Euhus, Charles F Timmons, Gail E Tomlinson  Cancer Cell  Volume 2, Issue 5, Pages 347-348 (November 2002) DOI: 10.1016/S1535-6108(02)00184-8

Figure 1 The t(12;15)(p13;q25) translocation fuses the ETV6 and NTRK3 genes presumably resulting in constitutive expression of NTRK3 tyrosine kinase activity The association of this fusion gene with malignancies as morphologically distinct as congenital mesoblastic nephroma and secretory breast cancer is notable. One case of acute myelogenous leukemia with a variant of the ETV6-NTK3 fusion gene has been reported (Eguchi et al., 1999). Cancer Cell 2002 2, 347-348DOI: (10.1016/S1535-6108(02)00184-8)