17 Chapter 17: Chromosome 17 Nucleus 48,473 bp 882 aa RARA Cytoplasm DNA Sequence Chromosome 48,473 bp Name of Protein 17 Name of Gene Promyelocytic leukemia protein RARA transcription Amino acid sequence mRNA 882 aa translation Cytoplasm Nucleus What does this protein make up or do? able to control cell growth and survival at many different levels Condition/Disease acute promyelocytic leukemia

Description of Glaucoma Symptoms and characteristics Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition. Symptoms of APL are:, Bleeding that is hard to stop, even from a small cut, Blood in the urine, Heavy nosebleeds, Bleeding gums and easy bruising, Fever and infections, Low red blood cell count, Paleness, Tiring easily. Certain signs and symptoms might suggest that a person could have acute myeloid leukemia (AML), but Tests that examine the blood and bone marrow are used to detect (find) and diagnose adult AML such as: Physical exam and history and a complete blood count. Granulocyte- CATEGORY OF WHITE BLOOD CELL.

Description of Glaucoma (cont.) Who is affected? For the most part everyone can get it. apl accounts for about 10 percent of acute myeloid leukemia cases. Acute promyelocytic leukemia occurs in approximately 1 in 250,000 people in the United States. Apl is not inherited but arises from a translocation in the body's cells that occurs after conception. Outlook or quality of life With early treatment, APL patient will have lower risks of a malignant apl level With no treatment APL will worsen and ne malignant. Treatments include induction & consolidation. Some patients may follow up with Maintenance. A cure for APL is now possible with treatments like atra and cancer chemotherapy drugs Researcher: iA

References http://ghr.nlm.nih.gov/condition/acute- promyelocytic-leukemia http://www.nature.com/cddis/journal/v3/n1/f ull/cddis2011122a.html http://www.ncbi.nlm.nih.gov/projects/genome/ guide/human/index.shtml http://www.cancer.org/cancer/leukemia- acutemyeloidaml/detailedguide/leukemia-acute- myeloid-myelogenous-diagnosed