Dr. Mauricio Rodriguez-Lanetty

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Effector mechanisms of humoral immunity The Complement System (C’) Activation pathways Effector functions Regulation of complement activation.

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Presentation transcript:

Dr. Mauricio Rodriguez-Lanetty PCB4233: Immunology Dr. Mauricio Rodriguez-Lanetty Email: rodmauri@fiu.edu Phone: 305-3484922 Lecture 6

Alternative Pathway of the Complement System

The alternative pathway Antigen-antibody Complex Classical pathway: C1 Pathogen surface C3 convertase Lectin pathway: MBL Pathogen carbohydrate (Mannose-binding Lectin) The alternative pathway

The alternative pathway of the complement activation can amplify the clasical or the lectin pathway

Opsonization Phagocytosis

Complement activated by the alternative pathway attacks pathogens while sparing host cells.

Recommended Reading for Complement System: Chapter 2

All mature blood (red and white) cells are derived from STEM CELLS Haematopoiesis is the formation of blood cellular components (red and white blood cells). All of the cellular components of the blood are derived from hematopoietic stem cells (HSC). They are self-renewing and Multipotent/ Pluripotent, as they can become any type of cell in the blood system

Where Haematopoesis occurs? In children: in long bones such as the femur and tibia. In Adults: in the pelvis, vertebrae, and sternum