The "Metabolically Healthy Obese"

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Presentation transcript:

The "Metabolically Healthy Obese"

Introduction/Overview

The Global Epidemic of Obesity

Obesity as a Risk Factor for a Range of Comorbid Conditions

Life Expectancy Decreases as BMI Increases

Who Are the Metabolically Healthy Obese?[a,b]

Pear-Shape vs Apple-Shape Body Fat Distribution

Phenotyping the "Metabolically Healthy Obese": Key Clinical Parameters

Clinical and Functional Characteristics: MHO vs MUO

Estimated Number of Cancer Cases (in Thousands) Attributable to Excess Body Mass

Post-Hoc Analysis Look AHEAD: The Importance of ≥10% Weight Loss

Mechanisms of Food Intake Regulation

Weight Loss Is Difficult, as Is Prevention of Weight Regain

Change in Weight From Baseline: Clinical Trial Data on 3 Approved Agents

Orlistat-Induced Weight Loss and Maintenance at 1 Year

SCALE: Change in Body Weight (%), Liraglutide vs Placebo

Weight Loss From Baseline for the Modified-ITT-LOCF Population and the Completer Population: Naltrexone + Bupropion vs Placebo

Targeting Multiple Physiologic Pathways in Energy Hemostasis and Weight Gain

Weight Loss and Prevention of New Disease Onset: Results of the SOS Study

AACE/TOS/ASMBS Guidelines: Criteria for Bariatric Surgery Recommendation

Obesity Is an Independent Risk Factor for CVD

Look AHEAD Results: Incidence of Very-High-Risk Chronic Kidney Disease by Treatment Group

Summary and Conclusions

Abbreviations

Abbreviations (cont)