AHA Northwestern Strategically-Focused Children’s Research Center

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Presentation transcript:

AHA Northwestern Strategically-Focused Children’s Research Center Early Life Origins of Cardiovascular Health: Healthier, Earlier A DevSci Healthier, Earlier Translational Partnership INTEGRATED INTERDISCIPLINARY COLLABORATIONS AHA SFRN NORTHWESTERN CENTER AIMS: Blend expertise in pediatric cardiology & neurodevelopment (PI Marino), and cardiovascular epidemiology & preventive medicine (Co-PI: Lloyd–Jones) to: Reduce burden of CVD by altering its developmental origins Establish a novel paradigm for measuring, monitoring, and modifying CVH trajectories in early life Assess the modifying effects of early life neurodevelopmental health and children's social environment on CVH trajectories Foster the next generation of translational scientists in CVH and neurodevelopment BUILDING AN EVIDENCE BASE FOR PROMOTING CVH HEALTH FROM BIRTH UNIFYING OBJECTIVE: CLOSE THE 0-8 GAP TO ENABLE PROMOTION OF CVH BEGINNING AT BIRTH CROSS-CUTTING OBJECTIVE: DISCOVER HOW EARLY NEURODEVELOPMENTAL HEALTH MODIFIES EMERGENT CVH POPULATION SCIENCE CVH Trajectories: Birth to Adolescence PI: Nori Allen, PhD, MPH Cardiovascular Epidemiologist, DPM/FSM Use big data methods to model developmental trajectories of CVH risk from 0-12 yrs. CLINICAL SCIENCE Keeping IDeal CVH Family Intervention Trial (KIDFIT): PI: Linda Van Horn, PhD, RD Nutrition Science, DMP/FSM Test the efficacy of a family based preschool obesity prevention a high risk sample Brad Marino, MD, MPP, MSCE, FAHA Pediatrician, PEDS/LCH Laurie Wakschlag, PhD Developmental Psychologist, MSS/FSM BASIC SCIENCE Characterizing Dynamic Epigenomic CVH Markers in Early Life PI: Lifang Hou, MD, PhD Genetic Epidemiology, DPM/FSM What are the molecular mechanisms and signals of CVH loss or preservation in early life? Elizabeth Norton, PhD Developmental Cognitive Neuroscientist, CSD/SOC